{"id":90576,"date":"2008-12-12T00:00:00","date_gmt":"2008-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-posibles-marcadores-proteicos-de-cancer-colorrectal-en-lineas-celulares-y-biopsias-humanas-utilizando-tecnicas-proteomicas\/"},"modified":"2008-12-12T00:00:00","modified_gmt":"2008-12-12T00:00:00","slug":"identificacion-de-posibles-marcadores-proteicos-de-cancer-colorrectal-en-lineas-celulares-y-biopsias-humanas-utilizando-tecnicas-proteomicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/identificacion-de-posibles-marcadores-proteicos-de-cancer-colorrectal-en-lineas-celulares-y-biopsias-humanas-utilizando-tecnicas-proteomicas\/","title":{"rendered":"Identificacion de posibles marcadores proteicos de cancer colorrectal en lineas celulares y biopsias humanas utilizando tecnicas proteomicas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Freije Leon <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal es la segunda causa de muerte por c\u00e1ncer  en los pa\u00edses desarrollados, con  m\u00e1s de 200.000 muertes en europa durante el a\u00f1o 2006. El desarrollo del c\u00e1ncer colorrectal espor\u00e1dico comprende m\u00faltiples pasos que conducen a un gran n\u00famero de alteraciones, de forma que son esperables cambios en la expresi\u00f3n proteica. En este estudio se ha empleado la aproximaci\u00f3n prote\u00f3mica basada en geles bidimensionales para la identificaci\u00f3n de posibles marcadores proteicos para el c\u00e1ncer colorrectal en dos modelos de estudio. En primer lugar mediante el uso de l\u00edneas celulares en las que se ha inducido la sobre-expresi\u00f3n de la prote\u00edna id1, la cual se ha observado que se encuentra sobre-expresada en diversos tipos de c\u00e9lulas y tejidos tumorales. La prote\u00edna id1 est\u00e1 involucrada en diversas rutas metab\u00f3licas relacionadas con la progresi\u00f3n y desarrollo en varios tipos de c\u00e1ncer. En un segundo estudio, se ha analizado el proteoma de biopsias humanas de colon para determinar  las diferencias a nivel proteico entre tejidos afectados por el c\u00e1ncer colorrectal y tejidos no tumorales o sanos. Como resultado, se ha observado que la expresi\u00f3n de las prote\u00ednas prohibitina, triosafosfato isomerasa y tiorredoxina se encuentra alterada en los tejidos tumorales. Adem\u00e1s, se ha determinado que la expresi\u00f3n de los genes tpm1 y tpm2 se encuentra reprimida a medida que avanza el desarrollo tumoral en tejidos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificacion de posibles marcadores proteicos de cancer colorrectal en lineas celulares y biopsias humanas utilizando tecnicas proteomicas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificacion de posibles marcadores proteicos de cancer colorrectal en lineas celulares y biopsias humanas utilizando tecnicas proteomicas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Freije Leon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Heredia Zorrilla<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Rodriguez arrondo <\/li>\n<li>Luis Torres asensi (vocal)<\/li>\n<li>Fernando Jos\u00e9 Corrales izquierdo (vocal)<\/li>\n<li>felix Elortza basterrika (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Freije Leon El c\u00e1ncer colorrectal es la segunda causa de muerte por c\u00e1ncer en los pa\u00edses [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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