{"id":90613,"date":"2008-12-12T00:00:00","date_gmt":"2008-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-celulas-imunocompetentes-de-bazo-y-timo-en-la-patogenia-de-la-diarrea-va%c2%adrica-bovina\/"},"modified":"2008-12-12T00:00:00","modified_gmt":"2008-12-12T00:00:00","slug":"papel-de-las-celulas-imunocompetentes-de-bazo-y-timo-en-la-patogenia-de-la-diarrea-va%c2%adrica-bovina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-animal\/papel-de-las-celulas-imunocompetentes-de-bazo-y-timo-en-la-patogenia-de-la-diarrea-va%c2%adrica-bovina\/","title":{"rendered":"Papel de las c\u00e9lulas imunocompetentes de bazo y timo en la patogenia de la diarrea v\u00edrica bovina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Raya Bermudez <\/strong><\/h2>\n<p>En este trabajo se estudiaron, mediante t\u00e9cnicas histopatol\u00f3gicas, inmunohistoqu\u00edmicas y ultraestructurales, los cambios producidos en el bazo y timo en el transcurso de la infecci\u00f3n con la cepa no citop\u00e1tica 7443 del virus de la diarrea bovina de tipo 1. La principal lesi\u00f3n observada fue la intensa depleci\u00f3n linfoide de la corteza del timo de los 6 a los 14 d\u00edas post-inoculaci\u00f3n, acompa\u00f1ada de un incremento de la apoptosis linfocitaria y una disminuci\u00f3n de la proliferaci\u00f3n de los linfocitos. El inicio de la depleci\u00f3n linfoide en el timo coincidi\u00f3 con la detecci\u00f3n del virus en este \u00f3rgano. Sin embargo, el efecto directo del virus sobre los linfocitos no justificar\u00eda por s\u00ed sola esta lesi\u00f3n, ya que la infecci\u00f3n de estas c\u00e9lulas fue escasa y no correspondi\u00f3 con la depleci\u00f3n. Esta depleci\u00f3n tampoco fue debida a un incremento de la producci\u00f3n de citoquinas proinflamatorias por los macr\u00f3fagos, ya que, aunque existi\u00f3 un incremento num\u00e9rico de estas c\u00e9lulas, este incremento no se acompa\u00f1\u00f3 de una activaci\u00f3n secretora.  a los 9 d\u00edas, el virus fue detectado en c\u00e9lulas ret\u00edculo-epiteliales, coincidiendo con una disminuci\u00f3n en la expresi\u00f3n de citoqueratinas. La replicaci\u00f3n del virus en estas c\u00e9lulas podr\u00eda explicar la intensa disminuci\u00f3n en el n\u00famero de linfocitos en proliferaci\u00f3n que tuvo lugar en la corteza. Asimismo, la alteraci\u00f3n de estas c\u00e9lulas pudo interferir con los fen\u00f3menos de selecci\u00f3n positiva de la corteza, justificando el incremento de la apoptosis de los linfocitos. En el bazo no existieron lesiones histop\u00ed\u00a0tol\u00f3gicas. El ant\u00edgeno v\u00edrico no fue detectado en este \u00f3rgano, y no tuvieron lugar cambios significativos en las diferentes poblaciones celulares que lo componen.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las c\u00e9lulas imunocompetentes de bazo y timo en la patogenia de la diarrea v\u00edrica bovina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las c\u00e9lulas imunocompetentes de bazo y timo en la patogenia de la diarrea v\u00edrica bovina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Raya Bermudez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jos\u00e9 Bautista P\u00e9rez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel \u00e1ngel Sierra plana <\/li>\n<li>elizabeth m. Liebler tenorio (vocal)<\/li>\n<li>Antonio Bernabe salazar (vocal)<\/li>\n<li>alejandro Nu\u00f1ez castel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Raya Bermudez En este trabajo se estudiaron, mediante t\u00e9cnicas histopatol\u00f3gicas, inmunohistoqu\u00edmicas y ultraestructurales, los cambios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,541],"tags":[85047,187976,1954,187977,146627,19519],"class_list":["post-90613","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-patologia-animal","tag-alejandro-nunez-castel","tag-ana-isabel-raya-bermudez","tag-antonio-bernabe-salazar","tag-elizabeth-m-liebler-tenorio","tag-maria-jose-bautista-perez","tag-miguel-angel-sierra-plana"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=90613"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/90613\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=90613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=90613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=90613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}