{"id":90692,"date":"2018-03-11T10:09:14","date_gmt":"2018-03-11T10:09:14","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hacia-un-nuevo-modelo-de-epilepsia-el-hamster-gashsal\/"},"modified":"2018-03-11T10:09:14","modified_gmt":"2018-03-11T10:09:14","slug":"hacia-un-nuevo-modelo-de-epilepsia-el-hamster-gashsal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/neuropatologia\/hacia-un-nuevo-modelo-de-epilepsia-el-hamster-gashsal\/","title":{"rendered":"Hacia un nuevo modelo de epilepsia: el h\u00e1mster gash:sal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Melissa Milagros Carballosa Gonzales <\/strong><\/h2>\n<p>La epilepsia es una e las enfermedades neurol\u00f3gicas m\u00e1s frecuentes en el hombre, desconoci\u00e9ndose actualmente los mecanismos celulares y moleculares que transforman una parte del cerebro normal en epil\u00e9ptico.El estudio de la epilepsias ha sido dependiente del estudio de diversos modelos animales. De entre todos los modelos,los de car\u00e1cter gen\u00e9tico,constituyen un grupo muy \u00fatil, y entre ellos, los que presentan epilepsias reflejas m\u00e1s a\u00fan, ya que pueden desencadenarse las crisis a voluntad al exponer al animal al est\u00edmulo causante de la epilepsia. El modelo animal para este estudio es una l\u00ednea de h\u00e1mster , gash:sal, desarrollada en el animalario de la universidad de salamanca que sufre crisis convulsivas audiogenas(cca). A la hora de estandarizar y establecer al h\u00e1mster gash:sal como nuevo modelo de epilepsia, confirmamos tras la inspecci\u00f3n visual de registros eeg sincronizados con la grabaci\u00f3n de v\u00eddeo, un patr\u00f3n caracter\u00edstico de una epilepsia generalizada de tipo t\u00f3nico-cl\u00f3nica. Al estudiar los cambios gen\u00e9ticos mediante la t\u00e9cnica de aflp (amplified fragment length polymorphism), hemos encontrado que existen diferencias significativas entre los gash:sal y los controles, diferencias que pueden, a su vez ser responsables de la susceptibilidad a padecer cca. Adem\u00e1s, hemos encontrado que los gash:sal presentan una funci\u00f3n auditiva deficiente,con umbrales auditivos muy elevados. Al realizar an\u00e1lisis de im\u00e1genes de tomograf\u00eda de emisi\u00f3n de positrones (pet) y densitometr\u00eda de la inmunotinci\u00f3n para visualizar la prote\u00edna fos, se aprecia una correlaci\u00f3n entre la inducci\u00f3n de cca y una mayor actividad en el col\u00edculo inferior, observada por una mayor captaci\u00f3n de glucosa y un aumento en la expresi\u00f3n de c-fos en relaci\u00f3n a los hamsters control, estando por tanto este n\u00facleo troncoencef\u00e1lico implicado en el inicio y\/o propagaci\u00f3n de las cca. Al realizar estos estudios, por medio de comparaci\u00f3n con otros modelos animales de epilepsia ya consolidados, hemos confirmado al h\u00e1mster gash:sal como un modelo v\u00e1lido de epilepsia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hacia un nuevo modelo de epilepsia: el h\u00e1mster gash:sal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hacia un nuevo modelo de epilepsia: el h\u00e1mster gash:sal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Melissa Milagros Carballosa Gonzales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Dolores Estilita Lopez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: raquel emilia Rodr\u00edguez rodr\u00edguez <\/li>\n<li>ver\u00f3nica Fuentes santamar\u00eda (vocal)<\/li>\n<li>carmen Mu\u00f1oz de la pascua (vocal)<\/li>\n<li>natividad Garc\u00eda atar\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Melissa Milagros Carballosa Gonzales La epilepsia es una e las enfermedades neurol\u00f3gicas m\u00e1s frecuentes en el hombre, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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