{"id":90726,"date":"2018-03-11T10:09:18","date_gmt":"2018-03-11T10:09:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-pirrolidinas-y-pirrolizidinas-con-actividad-inhibidora-de-glicosidasas-y-glicosiltransferasas\/"},"modified":"2018-03-11T10:09:18","modified_gmt":"2018-03-11T10:09:18","slug":"sa%c2%adntesis-de-pirrolidinas-y-pirrolizidinas-con-actividad-inhibidora-de-glicosidasas-y-glicosiltransferasas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/sa%c2%adntesis-de-pirrolidinas-y-pirrolizidinas-con-actividad-inhibidora-de-glicosidasas-y-glicosiltransferasas\/","title":{"rendered":"S\u00edntesis de pirrolidinas y pirrolizidinas con actividad inhibidora de glicosidasas y glicosiltransferasas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Celia Rib\u00e9s Vidal <\/strong><\/h2>\n<p>El objetivo de esta tesis es el desarrollo de nuevas estrategias sint\u00e9ticas para la s\u00edntesis de pirrolidinas y pirrolizidinas, aisladas de fuentes naturales,  con actividad inhibidora de glicosidasas y glicosiltransferasas.  en esta tesis se ha desarrollado una estrategia sint\u00e9tica estereoselectiva y vers\u00e1til que ha permitido la s\u00edntesis de las broussonetinas c, d, m, o y p. Siendo el paso clave una reacci\u00f3n de met\u00e1tesis cruzada entre un anillo de pirrolidina com\u00fan a todas las broussonetinas sintetizadas, sintetizado a partir del amino\u00e1cido d-serina, y las diferentes cadenas laterales de cada una de las broussonetinas. Dicha reacci\u00f3n le confiere a la estrategia sint\u00e9tica una gran versatilidad. Dicha estrategia sint\u00e9tica se ha aplicado en la s\u00edntesis de otros alcaloides polihidroxilados inhibidores de glicosidasas, que son la radicamina b, la nectrisina y la hiacintacina a2. Dichos compuestos han sido sintetizados a partir de diversos intermedios en la s\u00edntesis del anillo pirrolid\u00ednico de las broussonetinas.  Adem\u00e1s se ha desarrollado una nueva estrategia sint\u00e9tica para la s\u00edntesis del alcaloide pirrolizid\u00ednico australina.  otro objetivo sint\u00e9tico en esta tesis ha sido la anhidrofitoesfingosina jaspina b, sintetizada a partir del (r)-glicidol.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de pirrolidinas y pirrolizidinas con actividad inhibidora de glicosidasas y glicosiltransferasas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de pirrolidinas y pirrolizidinas con actividad inhibidora de glicosidasas y glicosiltransferasas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Celia Rib\u00e9s Vidal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Jaume i de castell\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eva Falomir Ventura<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Pedrosa saez <\/li>\n<li>sofia Barluenga badiola (vocal)<\/li>\n<li>ram\u00f3n Estevez cabanas (vocal)<\/li>\n<li>antoni Riera escale (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Celia Rib\u00e9s Vidal El objetivo de esta tesis es el desarrollo de nuevas estrategias sint\u00e9ticas para la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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