{"id":90748,"date":"2018-03-11T10:09:18","date_gmt":"2018-03-11T10:09:18","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-mecanismos-de-cancer-por-la-va%c2%ada-de-senalizacion-de-notch-silenciamiento-y-micrornas\/"},"modified":"2018-03-11T10:09:18","modified_gmt":"2018-03-11T10:09:18","slug":"nuevos-mecanismos-de-cancer-por-la-va%c2%ada-de-senalizacion-de-notch-silenciamiento-y-micrornas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/nuevos-mecanismos-de-cancer-por-la-va%c2%ada-de-senalizacion-de-notch-silenciamiento-y-micrornas\/","title":{"rendered":"Nuevos mecanismos de c\u00e1ncer por la v\u00edade se\u00f1alizaci\u00f3n de notch: silenciamiento y micrornas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diana Marcela Vallejo Mart\u00ednez <\/strong><\/h2>\n<p>Nuevos mecanismos de c\u00e1ncer por la v\u00eda de se\u00f1alizaci\u00f3n de notch: silenciamiento epigen\u00e9tico y micrornas  el tama\u00f1o y la forma distintiva de los \u00f3rganos y tejidos de un organismo est\u00e1 bajo estricto control gen\u00e9tico.  Sin embargo, y a pesar de la intensa investigaci\u00f3n en el campo, los mecanismos y genes que subyacen al control de la forma y el tama\u00f1o siguen siendo uno de las grandes inc\u00f3gnitas de la biolog\u00eda del desarrollo.  En la mosca del vinagre drosophila melanogaster, el control de la forma y del tama\u00f1o est\u00e1 ligado a la formaci\u00f3n de patrones.  La v\u00eda de se\u00f1alizaci\u00f3n de notch, conservada desde drosophila a humanos, es una de las principales v\u00edas del desarrollo que juegan un papel instructivo en este control. En vertebrados, la v\u00eda de se\u00f1alizaci\u00f3n de notch tambi\u00e9n desempe\u00f1a un papel fundamental en el control de la proliferaci\u00f3n, crecimiento, supervivencia, diferenciaci\u00f3n, y migraci\u00f3n durante el desarrollo de numerosos tejidos y \u00f3rganos y en la homeostasis de algunos tejidos adultos.  No es sorprendente, pues, que la  activaci\u00f3n an\u00f3mala de la v\u00eda de notch se haya asociada a la iniciaci\u00f3n y progresi\u00f3n de una gran variedad de tumores.  La presente tesis doctoral contribuye a entender los vers\u00e1tiles mecanismos por los que la activaci\u00f3n an\u00f3mala de esta v\u00eda, en sinergia con otros factores, puede provocar tumores como los factores epigen\u00e9ticos del grupo polycomb: pipsqueak y lola.  Este trabajo adem\u00e1s revela la funci\u00f3n de una familia conservada de micrornas en la modulaci\u00f3n de la se\u00f1alizaci\u00f3n notch a trav\u00e9s de su ligando serrate\/jagged en desarrollo y c\u00e1ncer.    palabras clave:  drosophila, desarrollo, notch, c\u00e1ncer, factores epigen\u00e9ticos,  micrornas<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos mecanismos de c\u00e1ncer por la v\u00edade se\u00f1alizaci\u00f3n de notch: silenciamiento y micrornas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos mecanismos de c\u00e1ncer por la v\u00edade se\u00f1alizaci\u00f3n de notch: silenciamiento y micrornas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diana Marcela Vallejo Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Dom\u00ednguez Castellano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: M\u00aa \u00e1ngela Nieto toledano <\/li>\n<li>Andr\u00e9s Aguilera l\u00f3pez (vocal)<\/li>\n<li>marco Milan kalbfleisch (vocal)<\/li>\n<li>marcos Malumbres mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diana Marcela Vallejo Mart\u00ednez Nuevos mecanismos de c\u00e1ncer por la v\u00eda de se\u00f1alizaci\u00f3n de notch: silenciamiento epigen\u00e9tico [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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