{"id":90856,"date":"2018-03-11T10:09:27","date_gmt":"2018-03-11T10:09:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/study-of-dyrk1a-kinase-in-central-nervous-system-development-implication-in-mouse-retina-development\/"},"modified":"2018-03-11T10:09:27","modified_gmt":"2018-03-11T10:09:27","slug":"study-of-dyrk1a-kinase-in-central-nervous-system-development-implication-in-mouse-retina-development","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-humana\/study-of-dyrk1a-kinase-in-central-nervous-system-development-implication-in-mouse-retina-development\/","title":{"rendered":"Study of dyrk1a kinase in central nervous system development: implication in mouse retina development."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ariadna Laguna Tuset <\/strong><\/h2>\n<p>El gen dyrk1a se localiza en una regi\u00f3n del cromosoma 21 humano que se ha asociado a alteraciones en el neurodesarrollo. Este trabajo muestra como cambios en la dosis g\u00e9nica de dyrk1a en el rat\u00f3n causan una alteraci\u00f3n en la celularidad de las capas internas de la retina y provocan alteraciones funcionales severas. Adem\u00e1s, la sobreexpresi\u00f3n de dyrk1a es la \u00fanica responsable de las alteraciones en la retina de los animales ts65dn, un modelo murino de s\u00edndrome de down. El control de la muerte celular programada es fundamental para el correcto desarrollo del sistema nervioso central. Este trabajo demuestra que la prote\u00edna quinasa dyrk1a es un regulador negativo de la v\u00eda intr\u00ednseca de apoptosis durante el desarrollo de la retina. Dyrk1a no afecta la proliferaci\u00f3n o especificaci\u00f3n de las c\u00e9lulas progenitoras, sino que regula el n\u00famero de c\u00e9lulas que mueren por apoptosis. La caspasa-9 es un nuevo sustrato de dyrk1a, y la fosforilaci\u00f3n de la caspasa en el residuo treonina 125 por dyrk1a protege las c\u00e9lulas de la retina de la muerte apopt\u00f3tica. Nuestros datos sugieren un modelo en el que una desregulaci\u00f3n de la respuesta apopt\u00f3tica en neuronas en diferenciaci\u00f3n podr\u00eda participar en la neuropatolog\u00eda de enfermedades que presentan una alteraci\u00f3n en la dosis g\u00e9nica de dyrk1a.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Study of dyrk1a kinase in central nervous system development: implication in mouse retina development.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Study of dyrk1a kinase in central nervous system development: implication in mouse retina development. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ariadna Laguna Tuset <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Lourdes Arbon\u00e9s De Rafael<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Gir\u00e1ldez orgaz <\/li>\n<li>enrique Javier de la rosa (vocal)<\/li>\n<li>paola Bovolenta nicolao (vocal)<\/li>\n<li>eul?lia Mart\u00ed (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ariadna Laguna Tuset El gen dyrk1a se localiza en una regi\u00f3n del cromosoma 21 humano que se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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