{"id":90877,"date":"2018-03-11T10:09:27","date_gmt":"2018-03-11T10:09:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/potenciales-evocados-en-las-astas-posteriores-de-la-medula-espinal-modulacion-mediada-por-receptores-opioides-en-tres-formas-de-hiperexcitabilidad-experimental\/"},"modified":"2018-03-11T10:09:27","modified_gmt":"2018-03-11T10:09:27","slug":"potenciales-evocados-en-las-astas-posteriores-de-la-medula-espinal-modulacion-mediada-por-receptores-opioides-en-tres-formas-de-hiperexcitabilidad-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/embriologia-humana\/potenciales-evocados-en-las-astas-posteriores-de-la-medula-espinal-modulacion-mediada-por-receptores-opioides-en-tres-formas-de-hiperexcitabilidad-experimental\/","title":{"rendered":"Potenciales evocados en las astas posteriores de la medula espinal: modulacion mediada por receptores opioides en tres formas de hiperexcitabilidad experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Itxaso Buesa Sobera <\/strong><\/h2>\n<p>El control end\u00f3geno del dolor regula la informaci\u00f3n somatosensorial que ingresa en la m\u00e9dula espinal siendo en primera instancia el control segmentario local el modulador de la hiperexcitabilidad de la m\u00e9dula espinal. En dicho control act\u00faan principalmente el amino\u00e1cido inhibitorio \u00e1cido gamma aminobutirico (gaba) y los receptores opioides. Es importante la influencia que ejerce la inhibici\u00f3n segmentaria sobre la fisiopatolog\u00eda del dolor ya que se piensa que alteraciones en la excitabilidad neuronal pueden disminuir la efectividad del sistema de control end\u00f3geno del dolor y la respuesta a analg\u00e9sicos opioides.  con el objeto de esclarecer la efectividad de diversos agonistas de receptores opioides hemos inducido tres formas de hiperexcitabilidad en la m\u00e9dula espinal que principalmente difieren entre s\u00ed por la naturaleza del est\u00edmulo nocivo y la reversibilidad de la hiperexcitabilidad (i) desinhibici\u00f3n inducida por antagonistas del gaba selectivos de los subtipos a y b (ii) potenciaci\u00f3n a largo plazo (plp) de potenciales evocados por fibras c por estimulaci\u00f3n tet\u00e1nica aferente (iii) un modelo de dolor neurop\u00e1tico por ligadura del nervio raqu\u00eddeo l5 (lnr).  en presencia de hiperexcitabilidad de las neuronas de las astas posteriores de la m\u00e9dula espinal, es preciso incrementar la concentraci\u00f3n de agonista opioide para reducir los potenciales evocados hasta niveles similares a los que se logran en ausencia de hiperexcitabilidad. En la plp y lnr hemos observado un aumento en la potencia de la morfina y adem\u00e1s en la lnr tambi\u00e9n hemos registrado un incremento de la potencia del agonista opioide ?, Debido en parte al efecto sin\u00e9rgico entre los subtipos \u00c2\u00b5 y ?.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Potenciales evocados en las astas posteriores de la medula espinal: modulacion mediada por receptores opioides en tres formas de hiperexcitabilidad experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Potenciales evocados en las astas posteriores de la medula espinal: modulacion mediada por receptores opioides en tres formas de hiperexcitabilidad experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Itxaso Buesa Sobera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jon Jatsu Azkue Barrenetxea<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Luis Bueno lopez <\/li>\n<li>Jos\u00e9 Javier Meana Martinez (vocal)<\/li>\n<li>Carlos Matute almau (vocal)<\/li>\n<li>Elena Pita calandre (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Itxaso Buesa Sobera El control end\u00f3geno del dolor regula la informaci\u00f3n somatosensorial que ingresa en la m\u00e9dula [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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