{"id":90946,"date":"2018-03-11T10:09:36","date_gmt":"2018-03-11T10:09:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-traduccion-de-p27kip1\/"},"modified":"2018-03-11T10:09:36","modified_gmt":"2018-03-11T10:09:36","slug":"regulacion-de-la-traduccion-de-p27kip1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oviedo\/regulacion-de-la-traduccion-de-p27kip1\/","title":{"rendered":"Regulacion de la traduccion de p27kip1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Aida Martinez Sanchez <\/strong><\/h2>\n<p>P27kip1 es un inhibidor de kinasas dependientes de ciclinas que juega un importante papel en distintos procesos celulares como control de la proliferaci\u00f3n celular, diferenciaci\u00f3n, migraci\u00f3n y apoptosis. El adecuado funcionamiento de estos procesos requiere, en la mayor\u00eda de los casos, un estricto control de los niveles de p27 en las c\u00e9lulas. En muchos casos, el control de la expresi\u00f3n de p27 se produce a trav\u00e9s de la regulaci\u00f3n de la traducci\u00f3n de su mrna. Los resultados obtenidos durante la realizaci\u00f3n de esta tesis han permitido determinar elementos reguladores de la traducci\u00f3n del mrna de p27 en su extremo 3#utr. As\u00ed, el microrna mir-181a es capaz de inhibir la traducci\u00f3n del mrna de p27 en c\u00e9lulas hl60 a trav\u00e9s de dos sitios de uni\u00f3n en el 3#utr de p27. Durante el proceso de diferenciaci\u00f3n, una disminuci\u00f3n de la expresi\u00f3n de mir-181a permite el incremento de la traducci\u00f3n de p27; adem\u00e1s que el aumento de la expresi\u00f3n de p27 es necesario para una completa diferenciaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la traduccion de p27kip1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la traduccion de p27kip1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Aida Martinez Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Cuesta Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Lopez otin <\/li>\n<li>Juan Zaldive torrente (vocal)<\/li>\n<li>amelia Nieto martin (vocal)<\/li>\n<li>susana De la luna gargantilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aida Martinez Sanchez P27kip1 es un inhibidor de kinasas dependientes de ciclinas que juega un importante papel [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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