{"id":90962,"date":"2018-03-11T10:09:36","date_gmt":"2018-03-11T10:09:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-factores-biologicos-del-adenocarcinoma-de-endometrio-y-su-relacion-con-la-supervivencia\/"},"modified":"2018-03-11T10:09:36","modified_gmt":"2018-03-11T10:09:36","slug":"estudio-de-los-factores-biologicos-del-adenocarcinoma-de-endometrio-y-su-relacion-con-la-supervivencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ginecologia\/estudio-de-los-factores-biologicos-del-adenocarcinoma-de-endometrio-y-su-relacion-con-la-supervivencia\/","title":{"rendered":"Estudio de los factores biol\u00f3gicos del adenocarcinoma de endometrio y su relaci\u00f3n con la supervivencia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Bou Serra <\/strong><\/h2>\n<p>Introducci\u00f3n: los factores pron\u00f3sticos utilizados en el adenocarcinoma de endometrio para predecir el riesgo de recurrencia son los relacionados con el tipo de tumor (subtipo histol\u00f3gico y grado de diferenciaci\u00f3n) y el estadio de diseminaci\u00f3n. Otros factores de tipo molecular o biol\u00f3gico se han propuesto por algunos autores como factores pron\u00f3sticos independientes de recurrencia y muerte por la enfermedad pero sin consenso entre todos los autores. Hip\u00f3tesis: adem\u00e1s de la existencia de factores quir\u00fargico-patol\u00f3gicos de reconocido valor pron\u00f3stico en el adenocarcinoma de endometrio, deben existir otros factores de tipo biol\u00f3gico o molecular que podr\u00edan definir con mayor exactitud el pron\u00f3stico individual de las pacientes con esta enfermedad. Material y m\u00e9todos: estudio retrospectivo sobre 282 casos tratados de adenocarcinoma de endometrio en el hospital universitario la fe de Valencia, desde junio de 1988 hasta junio de 2000. An\u00e1lisis de los factores pron\u00f3sticos recogidos de la literatura: 1) cl\u00ednicos: edad, paridad, obesidad, diabetes, menopausia, hipertensi\u00f3n arterial, antecedentes oncol\u00f3gicos familiares, sintomatolog\u00eda, demora en la consulta. 2) anal\u00edticos: marcadores tumorales (ca 125, cea, ca 199, scc, betahcg, ca 153), hematocrito, hemoglobina, plaquetas. 3) histopatol\u00f3gicos: tipo histol\u00f3gico, grado de diferenciaci\u00f3n, tipo de crecimiento tumoral (focal o difuso), infiltraci\u00f3n miometrial, afectaci\u00f3n del c\u00e9rvix, afectaci\u00f3n parametrial, afectaci\u00f3n anexial, met\u00e1stasis ganglionar, n\u00famero de ganglios extirpados, citolog\u00eda de lavado peritoneal, embolizaci\u00f3n vascular y linf\u00e1tica, patolog\u00eda uterina asociada, endometrio acompa\u00f1ante, estadio. 4) moleculares: receptores estrog\u00e9nicos citos\u00f3licos y nucleares, receptores de progesterona, receptor del factor de crecimiento epid\u00e9rmico, catepsina d, p s2, p 53, her-2\/neu, fases del ciclo celular (g0g1, s, g2m), ploid\u00eda. Se estudia su relaci\u00f3n con la supervivencia de modo univariante (m\u00e9todo de kaplan-meier, prueba de log rank), y multivariante (regresi\u00f3n del riesgo proporcional de cox), as\u00ed como las posibles relaciones entre los distintos factores (chi cuadrado, t de student). Resultados. Factores relacionados con la supervivencia en an\u00e1lisis univariante: edad >65 a\u00f1os, demora en consultar <6m, cea > 5ng\/ml, ca 125 >24 ui\/ml, hematocrito <35%, hemoglobina <12 g\/dl, receptores estrog\u00e9nicos citos\u00f3licos <30 fmol\/mg prot., Receptores estrog\u00e9nicos nucleares <30 fmol\/mg dna, catepsina d <30 pmol\/mg prot., Fase g2m >12,2%, tipo histol\u00f3gico no endometrioide, grado de diferenciaci\u00f3n 3, tipo de crecimiento tumoral difuso, invasi\u00f3n miometrial >50%, afectaci\u00f3n cervical, parametrial, ganglionar, citolog\u00eda peritoneal positiva, embolizaci\u00f3n vascular y linf\u00e1tica, estadio iii-iv de la figo. De forma multivariante el \u00fanico factor pron\u00f3stico independiente sobre la supervivencia ha sido la afectaci\u00f3n ganglionar.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los factores biol\u00f3gicos del adenocarcinoma de endometrio y su relaci\u00f3n con la supervivencia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los factores biol\u00f3gicos del adenocarcinoma de endometrio y su relaci\u00f3n con la supervivencia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Bou Serra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/12\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Asins Codo\u00f1er<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: lorenzo Abad Martinez <\/li>\n<li>alfonso Herruzo nalda (vocal)<\/li>\n<li>Antonio Cano s\u00e1nchez (vocal)<\/li>\n<li>Javier Iglesias guiu (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Bou Serra Introducci\u00f3n: los factores pron\u00f3sticos utilizados en el adenocarcinoma de endometrio para predecir el riesgo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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