{"id":91157,"date":"2018-03-11T10:09:49","date_gmt":"2018-03-11T10:09:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-respuesta-inmune-innata-por-la-protea%c2%adna-de-matriz-extracelular-tromboespondina-1\/"},"modified":"2018-03-11T10:09:49","modified_gmt":"2018-03-11T10:09:49","slug":"regulacion-de-la-respuesta-inmune-innata-por-la-protea%c2%adna-de-matriz-extracelular-tromboespondina-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-respuesta-inmune-innata-por-la-protea%c2%adna-de-matriz-extracelular-tromboespondina-1\/","title":{"rendered":"Regulaci\u00f3n de la respuesta inmune innata por la prote\u00edna de matriz extracelular tromboespondina-1."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Gema Martin Manso <\/strong><\/h2>\n<p>Null las trombospondinas (tsps) son glicoprote\u00ednas que se secretan a la matriz extracelular. Poseen una estructura de multidominios con sitios de uni\u00f3n a calcio (ca2 ). la tsp1 a menudo se regula negativamente durante la progresi\u00f3n tumoral e inhibe el cre cimiento tumoral cuando se re-expresa. Esta actividad se atribuye normalmente a la inhibici\u00f3n de la angiog\u00e9nesis,  aunque numerosos estudios sugieren que la tsp1 juega un papel importante en el reclutamiento de monocitos y de macr\u00f3fagos en tejidos qu e han sufrido alg\u00fan tipo de da\u00f1o y en focos inflamatorios. Adem\u00e1s, se ha observado un aumento en el infiltrado de macr\u00f3fagos en tumores que sobreexpresan tsp1. En la presente tesis doctoral se investiga el papel de la tsp1 en el reclutamiento de macr \u00f3fagos en el tumor. As\u00ed, los resultados obtenidos ponen de manifiesto la importancia de la tsp1 como modulador positivo de la inmunidad innata anti-tumoral aumentando el reclutamiento de macr\u00f3fagos y estimulando la citotoxicidad tumoral mediada por e species reactivas de ox\u00edgeno (ros).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la respuesta inmune innata por la prote\u00edna de matriz extracelular tromboespondina-1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la respuesta inmune innata por la prote\u00edna de matriz extracelular tromboespondina-1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Gema Martin Manso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/01\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David D. Roberts<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillermo (secretario) Velasco d\u00edez <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Gema Martin Manso Null las trombospondinas (tsps) son glicoprote\u00ednas que se secretan a la matriz extracelular. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[170921,147731,188938],"class_list":["post-91157","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-david-d-roberts","tag-guillermo-secretario-velasco-diez","tag-m-gema-martin-manso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=91157"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91157\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=91157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=91157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=91157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}