{"id":91198,"date":"2018-03-11T10:09:53","date_gmt":"2018-03-11T10:09:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/scfcdc4-regulates-msn2-and-msn4-dependent-gene-expression-to-counteract-hog1-induced-lethality\/"},"modified":"2018-03-11T10:09:53","modified_gmt":"2018-03-11T10:09:53","slug":"scfcdc4-regulates-msn2-and-msn4-dependent-gene-expression-to-counteract-hog1-induced-lethality","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/scfcdc4-regulates-msn2-and-msn4-dependent-gene-expression-to-counteract-hog1-induced-lethality\/","title":{"rendered":"Scfcdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alexandre Vendrell Arasa <\/strong><\/h2>\n<p>El complejo scfcdc4 regula la expresi\u00f3n de los genes que dependen de msn2 i msn4 para contrarestar la muerte inducida por hog1.  la activaci\u00f3n sostenida de hog1 lleva a una inhibici\u00f3n del crecimiento celular. En este trabajo, hemos observado que el fenotipo de letalidad causada por la activaci\u00f3n sostenida de hog1 es parcialment inhibida por la mutaci\u00f3n del complejo scfcdc4. La inhibici\u00f3n de la muerte causada por la activaci\u00f3n sostenida de hog1 depende de la via de extensi\u00f3n de la vida. Cuando hog1 se activa de manera sostenida, la mutaci\u00f3n en el complejo scfcdc4 hace que aumente la expressi\u00f3n g\u00e9nica dependiente de msn2 y msn4 que conduce a una sobreexpressi\u00f3n del gen pnc1 y a una hiperactivaci\u00f3n de la deacetilasa sir2. La hiperactivaci\u00f3n de sir2 es capaz de inhibir la muerte causada por la activaci\u00f3n sostenida de hog1. tambi\u00e9n hemos observado que la muerte celular causada por la activaci\u00f3n sostenida de hog1 es debida a una inducci\u00f3n de apoptosis. La apoptosis inducida por hog1 es inhibida por la mutaci\u00f3n en el complejo scfcdc4. Por lo tanto, la via de extensi\u00f3n de la vida es capaz de prevenir la apoptosis a trav\u00e9s de un mecanismo desconocido.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Scfcdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Scfcdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alexandre Vendrell Arasa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/01\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Posas Garriga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garcia de herreros madue\u00f1o <\/li>\n<li>markus Proft (vocal)<\/li>\n<li>josep Clotet erra (vocal)<\/li>\n<li>benjam\u00ed Pi\u00f1a cap\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alexandre Vendrell Arasa El complejo scfcdc4 regula la expresi\u00f3n de los genes que dependen de msn2 i [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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