{"id":91458,"date":"2018-03-11T10:10:12","date_gmt":"2018-03-11T10:10:12","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-del-fenotipo-y-localizacion-de-la-fraccion-celular-cd34-positiva-de-epidermis-humana\/"},"modified":"2018-03-11T10:10:12","modified_gmt":"2018-03-11T10:10:12","slug":"analisis-del-fenotipo-y-localizacion-de-la-fraccion-celular-cd34-positiva-de-epidermis-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/analisis-del-fenotipo-y-localizacion-de-la-fraccion-celular-cd34-positiva-de-epidermis-humana\/","title":{"rendered":"Analisis del fenotipo y localizacion de la fraccion celular cd34 positiva de epidermis humana"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Araika Gutierrez Rivera <\/strong><\/h2>\n<p>La epidermis requiere de una autorrenovaci\u00f3n continua mediada por las c\u00e9lulas madre epiteliales (cme). Estudios realizados en rat\u00f3n  sugieren que las c\u00e9lulas cd34+ constituyen la poblaci\u00f3n de cme murinas, tanto por localizaci\u00f3n -se sit\u00faan en la protuberancia de la vaina radicular externa (vre) que recubre el fol\u00edculo piloso, coincidiendo con la localizaci\u00f3n de las lrcs (label retaining cells, c\u00e9lulas que retienen el marcaje) y la queratina 15 (k15)- como por los resultados obtenidos en ensayos funcionales in vitro e in vivo. En contraste, las c\u00e9lulas cd34+ humanas se sit\u00faan en una regi\u00f3n suprabulbar de la vre y existe cierta controversia sobre qu\u00e9 poblaci\u00f3n celular constituye las cme humanas. Por ello, nuestro principal objetivo fue caracterizar fenot\u00edpicamente la fracci\u00f3n celular cd34+ de piel humana y determinar si la fracci\u00f3n celular cd34+ representa la poblaci\u00f3n de cme. La caracterizaci\u00f3n fenot\u00edpica de la fracci\u00f3n celular cd34+ aislada de biopsias de piel descart\u00f3 un posible origen hematopoy\u00e9tico y\/o endotelial de la misma y puso de manifiesto que  un porcentaje de la misma expresaba marcadores caracter\u00edsticos de cme. Sin embargo, la mayor\u00eda de las c\u00e9lulas cd34+ obtenidas de piel total fueron de origen d\u00e9rmico. La optimizaci\u00f3n del protocolo de aislamiento permiti\u00f3 la obtenci\u00f3n de cultivos de c\u00e9lulas cd34+ epid\u00e9rmicas y la realizaci\u00f3n de ensayos funcionales, concretamente ensayos de clonogenicidad, migraci\u00f3n in vitro y cultivos organot\u00edpicos. Los resultados presentados en esta tesis ponen de manifiesto que la fracci\u00f3n celular cd34+ epid\u00e9rmica humana no presenta caracter\u00edsticas funcionales propias de c\u00e9lula madre y por tanto no representa la poblaci\u00f3n de cme humana.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis del fenotipo y localizacion de la fraccion celular cd34 positiva de epidermis humana<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis del fenotipo y localizacion de la fraccion celular cd34 positiva de epidermis humana <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Araika Gutierrez Rivera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/01\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ander Izeta Permisan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miren pilare Cajaraville bereziartua <\/li>\n<li>Fernando Larcher laguzzi (vocal)<\/li>\n<li>cesar Trigueros fern\u00e1ndez (vocal)<\/li>\n<li>marcela Del rio nechaevsky (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Araika Gutierrez Rivera La epidermis requiere de una autorrenovaci\u00f3n continua mediada por las c\u00e9lulas madre epiteliales (cme). [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,212,115,9399,12909],"tags":[182009,189469,105061,128615,189470,188112],"class_list":["post-91458","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-humana","category-bioquimica-molecular","category-cultivo-celular","category-pais-vasco-euskal-herriko-unibertsitatea","tag-ander-izeta-permisan","tag-araika-gutierrez-rivera","tag-cesar-trigueros-fernandez","tag-fernando-larcher-laguzzi","tag-marcela-del-rio-nechaevsky","tag-miren-pilare-cajaraville-bereziartua"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91458","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=91458"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91458\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=91458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=91458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=91458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}