{"id":91557,"date":"2009-06-02T00:00:00","date_gmt":"2009-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/terapia-de-la-enfermedad-hepatica-experimental-mediante-trasplante-de-celulas-mononuclerares-de-sangre-de-cordon-umbilical-humano\/"},"modified":"2009-06-02T00:00:00","modified_gmt":"2009-06-02T00:00:00","slug":"terapia-de-la-enfermedad-hepatica-experimental-mediante-trasplante-de-celulas-mononuclerares-de-sangre-de-cordon-umbilical-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/terapia-de-la-enfermedad-hepatica-experimental-mediante-trasplante-de-celulas-mononuclerares-de-sangre-de-cordon-umbilical-humano\/","title":{"rendered":"Terapia de la enfermedad hep\u00e1tica experimental mediante trasplante de c\u00e9lulas mononuclerares de sangre de cord\u00f3n umbilical humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel \u00e1lvarez Mercado <\/strong><\/h2>\n<p>Las enfermedades hep\u00e1ticas suponen un alto coste para la sociedad ya que afectan aproximadamente al 17% de la poblaci\u00f3n mundial. El tratamiento actual de la enfermedad hep\u00e1tica terminal consiste en el trasplante de h\u00edgado, pero est\u00e1 limitado por la escasez de \u00f3rganos donantes. Adem\u00e1s, hoy d\u00eda no existe ning\u00fan tratamiento espec\u00edfico de la fibrosis que se desarrolla en las enfermedades hep\u00e1ticas cr\u00f3nicas. Nuestro grupo tiene como objetivo a largo plazo desarrollar una terapia dirigida al tratamiento de la enfermedad hep\u00e1tica. Los objetivos espec\u00edficos de este trabajo han consistido en investigar la capacidad de diferenciaci\u00f3n in vitro de las c\u00e9lulas mononucleares de sangre de cord\u00f3n umbilical humano (cmcuh) para comprobar si pueden transdiferenciarse en hepatocitos y si el trasplante de estas c\u00e9lulas resulta \u00fatil como tratamiento de la patolog\u00eda hep\u00e1tica.  hemos llevado a cabo experimentos de trasplante de cmcuh en dos modelos experimentales de enfermedad (agudo y cr\u00f3nico). El modelo agudo simula las alteraciones hep\u00e1ticas de la hepatitis v\u00edrica y no desarrolla fibrosis; el modelo cr\u00f3nico, en el que s\u00ed se forma una fibrosis intensa, mimetiza las lesiones de la cirrosis hep\u00e1tica. los resultados obtenidos apuntan a la adquisici\u00f3n in vitro de un fenotipo t\u00edpico de hepatocitos por parte de las c\u00e9lulas mononucleares humanas de sangre de cord\u00f3n de forma dependiente del tiempo y simult\u00e1nea a la p\u00e9rdida del fenotipo hematopoy\u00e9tico. Por otro lado, el trasplante de c\u00e9lulas mononucleares humanas procedentes de sangre de cord\u00f3n fue capaz de revertir las alteraciones histol\u00f3gicas y funcionales del h\u00edgado de ratas con hepatitis experimental producida por d-galactosamina. En cambio, la terapia con estas c\u00e9lulas no fue eficaz en el tratamiento de la cirrosis hep\u00e1tica experimental producida por la administraci\u00f3n cr\u00f3nica de tioacetamida. Al contrario, los hallazgos bioqu\u00edmicos e histol\u00f3gicos apuntan a que el trasplante celular provoc\u00f3 un s\u00edndrome hepato-renal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Terapia de la enfermedad hep\u00e1tica experimental mediante trasplante de c\u00e9lulas mononuclerares de sangre de cord\u00f3n umbilical humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Terapia de la enfermedad hep\u00e1tica experimental mediante trasplante de c\u00e9lulas mononuclerares de sangre de cord\u00f3n umbilical humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel \u00e1lvarez Mercado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Fontana Gallego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  dolores Suarez ortega <\/li>\n<li>Mar\u00eda victoria Garc\u00eda mediavilla (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Iraburu elizalde (vocal)<\/li>\n<li>carmelo Garcia monzon (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel \u00e1lvarez Mercado Las enfermedades hep\u00e1ticas suponen un alto coste para la sociedad ya que afectan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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