{"id":91577,"date":"2009-06-02T00:00:00","date_gmt":"2009-06-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-de-factores-de-transcripcion-estriatales-para-su-uso-en-la-diferenciacion-de-celulas-madre\/"},"modified":"2009-06-02T00:00:00","modified_gmt":"2009-06-02T00:00:00","slug":"caracterizacion-de-factores-de-transcripcion-estriatales-para-su-uso-en-la-diferenciacion-de-celulas-madre","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/caracterizacion-de-factores-de-transcripcion-estriatales-para-su-uso-en-la-diferenciacion-de-celulas-madre\/","title":{"rendered":"Caracterizaci\u00f3n de factores de transcripci\u00f3n estriatales para su uso en la diferenciaci\u00f3n de c\u00e9lulas madre"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noelia Urb\u00e1n Avellaneda <\/strong><\/h2>\n<p>El objetivo de esta tesis ha sido el estudio de dos factores gen\u00e9ticos implicados en la diferenciaci\u00f3n de las neuronas gaba\u00e9rgicas de proyecci\u00f3n estriatales: nolzl e ikaros. Adem\u00e1s se ha estudiado el potencial de estos factores de transcripci\u00f3n en la diferenciaci\u00f3n de c\u00e9lulas madre neurales in vitro hacia un fenotipo estrlatal para entender mejor los mecanismos que regulan la aparici\u00f3n de este tipo de neuronas. hemos demostrado que nolzl es un gen que interviene en la especificaci\u00f3n de los precursores neurales de la svz de la eminencia ganglionar lateral (lge), los llamados progenitores b\u00e1sales. Las c\u00e9lulas nolzl positivas provienen de precursores positivos para gsh2, y su expresi\u00f3n contribuye a la aparici\u00f3n de la se\u00f1alizaci\u00f3n de \u00e1cido retinoico en el n\u00facleo estriado durante el desarrollo. Nolzl, adem\u00e1s, regula la v\u00eda de notch en precursores neurales i promueve la aparici\u00f3n de precursores ollgodendrogliales mediante un mecanismo no aut\u00f3nomo en la lge. Por otra parte, demostramos que la isoforma de ikaros ik1 es esencial para la correcta generaci\u00f3n de las neuronas encefalin\u00e9rgicas estriatales a partir de la diferenciaci\u00f3n de precursores neurales dlx2 positivos de la lge. Mostramos que ik1 es necessario para sacar de ciclo los precursores que formar\u00e1n el n\u00facleo estriado med\u00edante el incremento de los niveles del inhibidor de cicl\u00ednas p21. En consonancia con esta observaci\u00f3n, la falta de ikaros durante el desarrollo, afecta la neurog\u00e9nesis tard\u00eda en el estriado.Esto se traduce en que el animal deficiente de ikaros presenta un n\u00facleo estriado m\u00e1s peque\u00f1o debido a una disminuci\u00f3n en el n\u00famero de neuronas de proyecci\u00f3n encefalin\u00e9rgicas de la matriz. As\u00ed, nolzl e ikaros intervienen en diferentes momentos del desarrollo estriatal, siendo el papel de nolzl anterior y centrado en el control de precursores neurales, y el de ikaros algo posterior, centrado en la diferenciaci\u00f3n de neuronas estriatales de proyecci\u00f3n encefalin\u00e9gicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n de factores de transcripci\u00f3n estriatales para su uso en la diferenciaci\u00f3n de c\u00e9lulas madre<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n de factores de transcripci\u00f3n estriatales para su uso en la diferenciaci\u00f3n de c\u00e9lulas madre <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noelia Urb\u00e1n Avellaneda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/02\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josep M. Canals Coll<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jordi Alberch i vie <\/li>\n<li>salvador Mart\u00ednez p\u00e9rez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noelia Urb\u00e1n Avellaneda El objetivo de esta tesis ha sido el estudio de dos factores gen\u00e9ticos implicados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,849,9399],"tags":[38170,189678,189677,33125],"class_list":["post-91577","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-celular","category-cultivo-celular","tag-jordi-alberch-i-vie","tag-josep-m-canals-coll","tag-noelia-urban-avellaneda","tag-salvador-Martinez-perez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=91577"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91577\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=91577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=91577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=91577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}