{"id":916,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/fijacion-de-propofol-a-proteinas-plasmaticas-estudio-experimental-y-clinico\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"fijacion-de-propofol-a-proteinas-plasmaticas-estudio-experimental-y-clinico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/fijacion-de-propofol-a-proteinas-plasmaticas-estudio-experimental-y-clinico\/","title":{"rendered":"Fijacion de propofol a proteinas plasmaticas. estudio experimental y clinico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Costela Villodres Jos\u00e9 Luis <\/strong><\/h2>\n<p>Se realizo un estudio experimental en ratones, evaluando la actividad de propofol en presencia y en ausencia de un desplazante del farmaco de sus sitios de fijacion a la albumina plasmatica: el sulfisoxazol. La medida de los efectos del propofol en 3 pruebas diferentes (el test de pasividad y el test de reflejo de enderezamiento del screening de irwing, y la prueba del rotarod) permitio demostrar una potenciacion tras la administracion de la sulfamida desplazante. La determinacion en plasma del propofol total y de la fraccion libre del mismo no mostraron diferencias entre los grupos a los que se administro sulfisoxazol y los grupos controles.  asimismo, se llevo a cabo un estudio clinico en el que se analizaron los niveles de propofol libre en muestras de sangre de pacientes de insuficiencia hepatica, insuficiencia renal y voluntarios sanos, asi como en enfermos dializados antes y despues de efectuada la dialisis. No se encontraron diferencias significativas en la fraccion libre de propofol en ninguno de los grupos analizados con respecto al obtenido en voluntarios sanos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Fijacion de propofol a proteinas plasmaticas. estudio experimental y clinico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Fijacion de propofol a proteinas plasmaticas. estudio experimental y clinico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Costela Villodres Jos\u00e9 Luis <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Raimundo Carlos Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Sergio Erill Saez <\/li>\n<li>Manuel Garcia Morillas (vocal)<\/li>\n<li>Alfonso Moreno Gonzalez (vocal)<\/li>\n<li>Rosario Calvo Duo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Costela Villodres Jos\u00e9 Luis Se realizo un estudio experimental en ratones, evaluando la actividad de propofol en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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