{"id":91753,"date":"2018-03-11T10:10:35","date_gmt":"2018-03-11T10:10:35","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/structural-studies-on-the-lysr-type-regulator-tsar\/"},"modified":"2018-03-11T10:10:35","modified_gmt":"2018-03-11T10:10:35","slug":"structural-studies-on-the-lysr-type-regulator-tsar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/structural-studies-on-the-lysr-type-regulator-tsar\/","title":{"rendered":"Structural studies on the lysr-type regulator tsar"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dominique Monferrer Ventura <\/strong><\/h2>\n<p>Caracterizaci\u00f3n estructural del regular tipo lysr de la bacteria comamonas testosteroni t-2, tsar, en estado s\u00f3lido por cristalograf\u00eda de rayos x y en soluci\u00f3n por difracci\u00f3n de rayos x a bajo \u00e1ngulo (saxs). Se han caracterizado las estructuras enteras de la prote\u00edna sola, en complejo con su inhibidor natural, p-toluensulfonato (tsa) y en complejo con sulfato, procedentes de cristales monocl\u00ednicos, y la estructura a baja resoluci\u00f3n de la prote\u00edna sola, procedente de cristales tetragonales. Las cuatro estructuras cristalinas revelan la misma estructura cuaternaria de tsar. Los datos de saxs revelan que tsar en soluci\u00f3n presenta la misma curva de difracci\u00f3n antes y despu\u00e9s de ser incubada con exceso de su efector natural, tsa; asimismo, los datos de saxs concuerdan con los datos derivados de las cuatro estructuras cristalinas. La conformaci\u00f3n de tsar es abierta y plana en comparaci\u00f3n con cbnr, hom\u00f3logo perteneciente a la misma familia de reguladores tipo lysr (lttr), que presenta una interacci\u00f3n adicional entre las llamadas h\u00e9lices de contacto. Un detallado an\u00ed\u00a0lisis  estructural y funciohnal de los lttrs que se han caracterizado hasta hoy lleva a proponer que la estructura de tsar representa la de un lttr-tipo activado mediante la uni\u00f3n con su efector natural, as\u00ed como el marco estructural para explicar el mecanismo de activaci\u00f3n general de todos los miembros de la familia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Structural studies on the lysr-type regulator tsar<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Structural studies on the lysr-type regulator tsar <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dominique Monferrer Ventura <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/02\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Us\u00f3n Finkenzeller<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ernest Giralt lledo <\/li>\n<li>ehmke Pohl (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dominique Monferrer Ventura Caracterizaci\u00f3n estructural del regular tipo lysr de la bacteria comamonas testosteroni t-2, tsar, en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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