{"id":91808,"date":"2018-03-11T10:10:39","date_gmt":"2018-03-11T10:10:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-antibioticos-en-streptomyces-y-su-relacion-con-el-metabolismo-global\/"},"modified":"2018-03-11T10:10:39","modified_gmt":"2018-03-11T10:10:39","slug":"sa%c2%adntesis-de-antibioticos-en-streptomyces-y-su-relacion-con-el-metabolismo-global","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-de-antibioticos-en-streptomyces-y-su-relacion-con-el-metabolismo-global\/","title":{"rendered":"S\u00edntesis de antibi\u00f3ticos en streptomyces y su relaci\u00f3n con el metabolismo global."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Ribelles De La Vega <\/strong><\/h2>\n<p>Apart from oleandomycin and oviedomycin, streptomyces antibioticus has a biosynthetic cluster that codes for an unidentified polyketide derived from the condensation of acetyl-coa. In addition to the structural genes needed for the synthesis of the compound, this cluster contains a pathway specific regulator (orfi). In addition, the cluster contains a two component system (orfd1\/orfd2) which specifically induces orfi transcription. In this work, by using footprint analysis we\u00c2\u00bfve elucidated the target sequence recognized by orfd1 within the promoter sequence of orfi. this regulatory mechanism has been used under heterologous conditions as a model system to study the regulatory process that leads to antibiotic biosynthesis in streptomyces coelicolor. For such purposes, genomic analysis has been conducted in the resulting strains. the studies undertaken led to the following conclusions: (a) the synthesis of the polyketide antibiotic actinorhodin goes together with an increase in the transcription rates of its pathway specific regulator: actii-orf4; (b) there is a correlation between the synthesis of actinorhodin and the activation of the genes involved in the oxidative stress response. the search for genes in s. Coelicolor that are similar to orfd1\/orfd2 two component system in s. Antibioticus, resulted in the characterization of the sco2307\/sco2308 two component system. This proteins work as a possible regulator for the synthesis of actinorhodin, cda, tha chaplins, the rodlins y the nitrogen metabolism.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis de antibi\u00f3ticos en streptomyces y su relaci\u00f3n con el metabolismo global.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis de antibi\u00f3ticos en streptomyces y su relaci\u00f3n con el metabolismo global. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Ribelles De La Vega <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/02\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Malpartida Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  pedro Garc\u00eda ballesta <\/li>\n<li>Mar\u00eda enriqueta Arias fern\u00e1ndez (vocal)<\/li>\n<li>Jes\u00fas Aparicio fernandez (vocal)<\/li>\n<li>M\u00aa carmen M\u00e9ndez fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Ribelles De La Vega Apart from oleandomycin and oviedomycin, streptomyces antibioticus has a biosynthetic cluster that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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