{"id":91859,"date":"2018-03-11T10:10:44","date_gmt":"2018-03-11T10:10:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-dels-mecanismes-moleculars-implicats-en-la-sensibilitzacio-a-laapoptosi-en-ca%c2%a8l-lules-de-carcinoma-daendometri\/"},"modified":"2018-03-11T10:10:44","modified_gmt":"2018-03-11T10:10:44","slug":"estudi-dels-mecanismes-moleculars-implicats-en-la-sensibilitzacio-a-laapoptosi-en-ca%c2%a8l-lules-de-carcinoma-daendometri","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-clinica\/estudi-dels-mecanismes-moleculars-implicats-en-la-sensibilitzacio-a-laapoptosi-en-ca%c2%a8l-lules-de-carcinoma-daendometri\/","title":{"rendered":"Estudi dels mecanismes moleculars implicats en la sensibilitzaci\u00f3 a l\u00c2\u00bfapoptosi en c\u00e9l.lules de carcinoma d\u00c2\u00bfendometri"},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Llobet Navas <\/strong><\/h2>\n<p>L#objectiu principal d#aquest treball ha estat identificar i caracteritzar els mecanismes moleculars pels quals les c\u00e9l.Lules de carcinoma d#endometri evadeixen la mort cel.Lular en resposta a diferents ter\u00ed\u00a0pies antitumorals.  l#obra s#enmarca en l#estudi de la senyalitzaci\u00f3 per receptors de mort, concretament per trail i fas, per\u00ed\u00b2 tamb\u00e9 s#han utilitzat altres agents que actualment ja s#estan utilitzant en pacients en el tractament d#altres neopl\u00ed\u00a0sies com el mieloma m\u00faltiple o el carcinoma de rony\u00f3 i que, com en aquest treball, continuen essent objecte d#estudi per una possible aplicaci\u00f3 en altres tipus de tumors. en aquest treball s#ha intentat realitzar un an\u00ed\u00a0lisi de la senyalitzaci\u00f3 iniciada pels lligands trail i fas tenint en compte la seva possible utilitat com a ter\u00ed\u00a0pia per si sola o en combinaci\u00f3 amb altres drogues. Per realitzar-lo s#ha treballat principalment en el cultiu de l\u00ednies cel.Lulars de carcinoma d#endometri i tamb\u00e9 amb cultius primaris de bi\u00ed\u00b2psies de pacients. en primer lloc hem determinat que les c\u00e9l.Lules canceroses endometrioides s\u00f3n resistents als tractaments convencionals a trav\u00e9s de receptors de mort i hem identificat el que esdev\u00e9 el primer mecanisme de resist\u00e9ncia en aquestes c\u00e9l.Lules: flip. Hem observat que l#inhibici\u00f3 de l#expressi\u00f3 de flip mitjan\u00ed\u00a7ant rna d#interfer\u00e9ncia sensibilitza les c\u00e9l.Lules de carcinoma d#endometri a l#apoptosi induida per trail i fas. Tamb\u00e9 s#ha pogut observar que flip es troba sobreexpressat en aproximadament el 40% dels carcinomes d#endometri. A partir d#aqu\u00ed, tot l#estudi es focalitza principalment en desxifrar quines prote\u00ed\u00afnes s\u00f3n les encarregades de modular l#expressi\u00f3 i estabilitat d#aquesta proteina. \u00e9s en aquest context on al llarg del temps ens hem anat trobant prote\u00ed\u00afnes com la casein cinasa-2 (ck2), b-raf o  la cinasa supressora de ras 1 (ksr1); totes elles implicades en la regulaci\u00f3 de la mort indu\u00ed\u00afda per trail i fas a trav\u00e9s de flip. hem pogut comprovar que la casein cinasa-2 \u00e9s capa\u00ed\u00a7 de regular a nivell d#expressi\u00f3 g\u00e9nica i a nivell postraduccional l#estabilitat de flip i com l#\u00fas tant d#inhibidors farmacol\u00ed\u00b2gics de l#activitat ck2 com de shrna enfront la subunitat reguladora de ck2 (ck2\u00edY) sensibilitza aquestes c\u00e9l.Lules al tractament per trail i fas. Tamb\u00e9 s#ha pogut comprovar fent \u00fas d#un array matricial de teixits que ck2\u00edY es trova altament expressada en el carcinoma d#endometri refor\u00ed\u00a7ant aix\u00ed els resultats dels nostres estudis previs.  finalment tampoc hem menystingut el que possiblement sigui l#objectiu \u00faltim en el camp de la recerca oncol\u00f3gica, \u00e9s a dir, l#aplicaci\u00f3 pr\u00ed\u00a0ctica, el disseny i desenvolupament de drogues candidates a ser administrades en pacients humans. \u00e9s per aquesta ra\u00f3 que tamb\u00e9 ens hem centrat en l#estudi dels efectes que determinades drogues (que actualment ja han assolit totes les fases cl\u00edniques) com el sorafenib o el bortezomib  puguin tenir en el carcinoma d#endometri.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi dels mecanismes moleculars implicats en la sensibilitzaci\u00f3 a l\u00c2\u00bfapoptosi en c\u00e9l.lules de carcinoma d\u00c2\u00bfendometri<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi dels mecanismes moleculars implicats en la sensibilitzaci\u00f3 a l\u00c2\u00bfapoptosi en c\u00e9l.lules de carcinoma d\u00c2\u00bfendometri <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Llobet Navas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/02\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>guiu Guia Matias<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mart\u00ed Aldea malo <\/li>\n<li>gema Moreno bueno (vocal)<\/li>\n<li>Juan  Manuel Zapata hernandez (vocal)<\/li>\n<li>Jos\u00e9 Palacios calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Llobet Navas L#objectiu principal d#aquest treball ha estat identificar i caracteritzar els mecanismes moleculars pels quals [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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