{"id":91898,"date":"2018-03-11T10:10:44","date_gmt":"2018-03-11T10:10:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/epidemiologa%c2%ada-molecular-y-control-de-vertical-del-vih-1-en-un-area-endemica-de-malaria-del-sur-de-mozambique\/"},"modified":"2018-03-11T10:10:44","modified_gmt":"2018-03-11T10:10:44","slug":"epidemiologa%c2%ada-molecular-y-control-de-vertical-del-vih-1-en-un-area-endemica-de-malaria-del-sur-de-mozambique","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia-clinica\/epidemiologa%c2%ada-molecular-y-control-de-vertical-del-vih-1-en-un-area-endemica-de-malaria-del-sur-de-mozambique\/","title":{"rendered":"Epidemiolog\u00eda molecular y control de vertical del vih-1 en un \u00e1rea end\u00e9mica de malaria del sur de mozambique"},"content":{"rendered":"

Tesis doctoral de Mar\u00eda Lahuerta Sana\u00fa <\/strong><\/h2>\n

Objetivos 1. Caracterizar la epidemiolog\u00eda molecular del vih-1 en mujeres embarazadas en manhi\u00ed\u00a7a, mozambique, y analizar la evoluci\u00f3n gen\u00e9tica entre 1999 y 2004. 2. Evaluar el impacto del tratamiento intermitente antimal\u00e1rico (iptp) con dos dosis de sulfadoxina-pirimetamina (sp) durante el 2\u00c2\u00b0 y 3o trimestre del embarazo en la transmisi\u00f3n vertical del vih-1. 3. Evaluar la relaci\u00f3n entre la infecci\u00f3n materna por p. Falciparum y la activaci\u00f3n del sistema inmunitario en el momento del parto en mujeres embarazadas vih-positivas. conclusiones 1. Todas las secuencias analizadas tanto de 1999 como del 2004 pertenec\u00edan al subtipo c y presentaban gran variaci\u00f3n gen\u00e9tica con la existencia de diferentes sublinajes circulantes del subtipo c. 2. Los resultados del an\u00e1lisis de divergencia gen\u00e9tica de estas secuencias sugieren que en la diversificaci\u00f3n viral estuvieron implicadas fuerzas de selecci\u00f3n positivas (mutaciones en amino\u00e1cidos que mejoran la aptitud del virus). 3. No observamos diferencias significativas en la carga viral o en el riesgo de mtct del vih-1 entre el grupo sp y el placebo, a pesar de que el sp consigui\u00f3 reducir significativamente la malaria perif\u00e9rica y la malaria placentaria activa. 4. La carga viral plasm\u00e1tica del vih-1 estaba asociada con un incremento del riesgo de mtct del vih-1. 5. Las mujeres con anemia (hematocrito<33%) en este estudio ten\u00edan un riesgo hasta 4 veces mayor de mtct de vih-1 que las mujeres sin anemia y est\u00e1 relaci\u00f3n era independiente de la carga viral plasm\u00e1tica del vih -1, del grupo de tratamiento y de la infecci\u00f3n por p. Falciparum. 6. La malaria placentaria (tanto activa como pasada) estaba asociada con un menor riesgo de mtct del vih-1 en el an\u00e1lisis multivariado. 7. Las mujeres vih-positivas con malaria perif\u00e9rica ten\u00edan niveles significativamente mayores de il-10 y mip-1 que las mujeres sin malaria perif\u00e9rica. 8. No se observ\u00f3 ninguna diferencia significativa entre las mujeres con y sin malaria placentaria para ninguna de las citoquinas placentarias analizadas. palabras clave: vih-1, plasmodium falciparum, transmisi\u00f3n vertical, \u00e1frica, anemia, subtipos vih-1, citoquinas.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abEpidemiolog\u00eda molecular y control de vertical del vih-1 en un \u00e1rea end\u00e9mica de malaria del sur de mozambique<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 Epidemiolog\u00eda molecular y control de vertical del vih-1 en un \u00e1rea end\u00e9mica de malaria del sur de mozambique <\/li>\n
  • Autor:<\/strong>\u00a0 Mar\u00eda Lahuerta Sana\u00fa <\/li>\n
  • Universidad:<\/strong>\u00a0 Barcelona<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 26\/02\/2009<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Denise Naniche<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: jordi Casabona barbara <\/li>\n
        • Jos\u00e9 Alcami pertejo (vocal)<\/li>\n
        • (vocal)<\/li>\n
        • (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Mar\u00eda Lahuerta Sana\u00fa Objetivos 1. Caracterizar la epidemiolog\u00eda molecular del vih-1 en mujeres embarazadas en manhi\u00ed\u00a7a, mozambique, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,1085,1086,597,967],"tags":[190265,71384,22623,190264],"class_list":["post-91898","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-enfermedades-infecciosas","category-epidemiologia","category-microbiologia-clinica","category-salud-publica","tag-denise-naniche","tag-jordi-casabona-barbara","tag-jose-alcami-pertejo","tag-maria-lahuerta-sanau"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=91898"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/91898\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=91898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=91898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=91898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}