{"id":91970,"date":"2018-03-11T10:10:53","date_gmt":"2018-03-11T10:10:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-y-expresion-genica-de-pros1-gas6-y-los-receptores-tam-en-patologa%c2%ada-vascular\/"},"modified":"2018-03-11T10:10:53","modified_gmt":"2018-03-11T10:10:53","slug":"variabilidad-y-expresion-genica-de-pros1-gas6-y-los-receptores-tam-en-patologa%c2%ada-vascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/variabilidad-y-expresion-genica-de-pros1-gas6-y-los-receptores-tam-en-patologa%c2%ada-vascular\/","title":{"rendered":"Variabilidad y expresi\u00f3n g\u00e9nica de pros1, gas6 y los receptores tam en patolog\u00eda vascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Bego\u00f1a Hurtado Villarejo <\/strong><\/h2>\n<p>\u00abenfermedad vascular\u00bb es un t\u00e9rmino general para describir al conjunto de patolog\u00edas que afectan a los sistemas vascular y circulatorio, entre las que se encuentran las enfermedades analizadas en esta tesis: la enfermedad tromboemb\u00f3lica, la aterosclerosis y la enfermedad cerebrovascular. Todas ellas son enfermedades complejas en las que intervienen m\u00faltiples factores gen\u00e9ticos y ambi\u00e9ntales y se ha apuntado al posibilidad de que compartan mecanismos patog\u00e9nicos comunes (cambien y tiret,2005).  en este contexto las principales prote\u00ednas estudiadas en esta tesis, la prote\u00edna s (ps) y el factor 6 especifico de parada celular o growth arrested specfic gene 6 (gas6), no solo est\u00e1n relacionadas con estas enfermedades vasculares, sino que comparten caracter\u00edsticas comunes a nivel de estructura y funci\u00f3n proteica y de estructura g\u00e9nica, ya que son par\u00e1logas, es decir, los genes que codifican para ambas prote\u00ednas provienen de un gen ancestral com\u00fan, que se ha diversificado de forma independiente durante el proceso evolutivo. El trabajo que se presenta a continuaci\u00f3n se fundamenta en la evidencia de una imbricaci\u00f3n, a diferentes niveles, entre los sistemas inflamatorio y hemost\u00e1tico con consecuencias en las enfermedades estudiadas, esto es la trombosis, la enfermedad ateroscler\u00f3tica y la enfermedad cerebrovascular asociada a aterosclerosis carotidea.  la prote\u00edna s es bien conocida  por su actividad anticoagulante y protectora del desarrollo de trombosis venosas (castoldi y hackeng, 2008). Gas6, mediante su interacci\u00f3n con receptores tirosina quinasa tam (tyro3,axl y mertk), se ha asociado a distintas enfermedades complejas, como enfermedad cardio y cerebrovascular, c\u00e1ncer y enfermedades inflamatorias, entre otras (bellido- martin y garcia de frutos, 2008). La descripci\u00f3n de la anticoagulante, en la homeostasis vascular.  este trabajo profundiza en la patolog\u00eda molecular asociada a la deficiencia de prote\u00edna s y la trombosis venosa y explora el papel de esta prote\u00edna, as\u00ed como la de su par\u00e1loga gas6 y los receptores celulares de ambas, os receptores tam, en la aterosclerosis carotidea y la enfermedad cerebrovascular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variabilidad y expresi\u00f3n g\u00e9nica de pros1, gas6 y los receptores tam en patolog\u00eda vascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variabilidad y expresi\u00f3n g\u00e9nica de pros1, gas6 y los receptores tam en patolog\u00eda vascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Bego\u00f1a Hurtado Villarejo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>N\u00faria Sala Serra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan carles Reverter <\/li>\n<li>sara Larriba bartolom\u00e9 (vocal)<\/li>\n<li>eduard Serra arenas (vocal)<\/li>\n<li>jerzy Krupinski (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Bego\u00f1a Hurtado Villarejo \u00abenfermedad vascular\u00bb es un t\u00e9rmino general para describir al conjunto de patolog\u00edas que afectan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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