{"id":92057,"date":"2009-05-03T00:00:00","date_gmt":"2009-05-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/design-and-synthesis-of-peptides-that-neutralize-bacterial-endotoxins-as-therapeutic-agents-for-the-treatment-of-sepsis\/"},"modified":"2009-05-03T00:00:00","modified_gmt":"2009-05-03T00:00:00","slug":"design-and-synthesis-of-peptides-that-neutralize-bacterial-endotoxins-as-therapeutic-agents-for-the-treatment-of-sepsis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/design-and-synthesis-of-peptides-that-neutralize-bacterial-endotoxins-as-therapeutic-agents-for-the-treatment-of-sepsis\/","title":{"rendered":"Design and synthesis of peptides that neutralize bacterial endotoxins as therapeutic agents for the treatment of sepsis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Mas Moruno <\/strong><\/h2>\n<p>La sepsis es un s\u00edndrome muy complejo de definir, diagnosticar y tratar. La patolog\u00eda de la sepsis se deriva de una respuesta perjudicial del organismo a una infecci\u00f3n. La exposici\u00f3n a endotoxinas bacterianas induce una respuesta sist\u00e9mica inflamatoria que tiene como finalidad luchar contra la infecci\u00f3n. Esta respuesta se puede describir con una serie de s\u00edntomas cl\u00ednicos como la fiebre o un aumento en la frecuencia cardiaca y respiratoria, entre otros. Este proceso, necesario para la defensa del organismo, conduce a la destrucci\u00f3n de los pat\u00f3genos. Pero si todo y activar estos mecanismos, la infecci\u00f3n persiste as\u00ed como la exposici\u00f3n del organismo a productos bacterianos nocivos, los s\u00edntomas cl\u00ednicos descritos pueden agravarse derivando en una septicemia. Las septicemias en un gran n\u00famero de casos progresan a estadios m\u00e1s graves, como las septicemias severas o el shock s\u00e9ptico, que acostumbran a comportar un fallo generalizado de \u00f3rganos vitales y la muerte del paciente. Las septicemias son la primera causa de mortalidad en las unidades de cuidados intensivos, con una mortalidad que varia entre el 30 y el 70%. En los estados unidos, el n\u00famero de pacientes con septicemia supera ya los 750.000 casos anuales, siendo la d\u00e9cima causa de mortalidad. Estas cifras son parecidas en europa. el lipopolisac\u00e1rido (lps) es la mol\u00e9cula que origina la septicemia y todas sus variantes, y es responsable de un gran nombre de enfermedades infecciosas. Esta mol\u00e9cula es el componente mayoritario de la pared celular de les bacterias gram-negativas. La estructura qu\u00edmica del lps se basa en dos dominios unidos covalentemente y claramente diferenciados. Una parte hidrof\u00edlica formada por unidades repetitivas de oligosac\u00e1ridos, y una parte lip\u00eddica, conocida como el l\u00edpido a que confiere toxicidad a la mol\u00e9cula. la presente tesis doctoral explora el dise\u00f1o, la s\u00edntesis y la evaluaci\u00f3n biol\u00f3gica de p\u00e9ptidos con capacidad para neutralizar el lps, a partir de prote\u00ednas de uni\u00f3n al lps. Tambi\u00e9n se examina el dise\u00f1o de inhibidores de tipo pept\u00eddico, con actividad biol\u00f3gica y propiedades farmacocin\u00e9ticas mejoradas. Finalmente se estudia una familia de peptidomim\u00e9ticos, peptoides, para neutralizar el lps. Estos compuestos resultaron ser incapaces para neutralizar esta endotoxina, pero demostraron ser citot\u00f3xicos frente diversas l\u00edneas tumorales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Design and synthesis of peptides that neutralize bacterial endotoxins as therapeutic agents for the treatment of sepsis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Design and synthesis of peptides that neutralize bacterial endotoxins as therapeutic agents for the treatment of sepsis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Mas Moruno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Albericio Palomera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: david Andreu mart\u00ednez <\/li>\n<li>enrique Perez paya (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Mas Moruno La sepsis es un s\u00edndrome muy complejo de definir, diagnosticar y tratar. La patolog\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,17,416],"tags":[190566,5628,34359,1099],"class_list":["post-92057","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-quimica","category-quimica-organica","tag-carlos-mas-moruno","tag-david-andreu-Martinez","tag-enrique-perez-paya","tag-fernando-albericio-palomera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/92057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=92057"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/92057\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=92057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=92057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=92057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}