{"id":9211,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/simulacion-por-ordenador-de-complejos-constituidos-por-adn-y-farmacos-intercalantes\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"simulacion-por-ordenador-de-complejos-constituidos-por-adn-y-farmacos-intercalantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/simulacion-por-ordenador-de-complejos-constituidos-por-adn-y-farmacos-intercalantes\/","title":{"rendered":"Simulacion por ordenador de complejos constituidos por adn y farmacos intercalantes."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Gallego Sala <\/strong><\/h2>\n<p>Mediante tecnicas computacionales, se muestra la influencia de las interacciones de apilamiento en la especificidad de secuencia de varios antibioticos que se unen al adn por intercalacion. Las transiciones al esquema de apareamiento hoogsteen detectadas en complejos adn-equinomicina pueden explicarse analizando las interacciones electrostaticas entre los cromoforos del bis-intercalante y los pares de bases del adn. Sobre esta base tambien se justifican los cambios de especificidad observados para la interaccion de la equinomicina con adn modificado, y la union selectiva del cysmetandem y de la actinomicina d al adn. Adicionalmente, se ha descrito por primera vez el potencial electrostatico molecular en torno a un par de bases a:t en conformacion hoogsteen, comprobando que este esquema de apareamiento conlleva un fuerte aumento de polaridad respecto al esquema habitual watson-crick.  las conclusiones derivadas del estudio de estos antibioticos naturales pueden aplicarse al dise\u00f1o racional de nuevos agentes intercalantes y bisintercalantes con especificidad de secuencia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Simulacion por ordenador de complejos constituidos por adn y farmacos intercalantes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Simulacion por ordenador de complejos constituidos por adn y farmacos intercalantes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Gallego Sala <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico Gago Badenas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jose Elguero Bertolini <\/li>\n<li>Jos\u00e9 Portugal Minguela (vocal)<\/li>\n<li>Modesto Orozco L\u00f3pez (vocal)<\/li>\n<li>Marta Bruix Bayes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Gallego Sala Mediante tecnicas computacionales, se muestra la influencia de las interacciones de apilamiento en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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