{"id":92177,"date":"2009-12-03T00:00:00","date_gmt":"2009-12-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/differentiation-of-spinal-cord-neural-precursors-and-hippocampal-neurons-a-role-for-wnt-and-b-catenin\/"},"modified":"2009-12-03T00:00:00","modified_gmt":"2009-12-03T00:00:00","slug":"differentiation-of-spinal-cord-neural-precursors-and-hippocampal-neurons-a-role-for-wnt-and-b-catenin","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/morfologia-celular\/differentiation-of-spinal-cord-neural-precursors-and-hippocampal-neurons-a-role-for-wnt-and-b-catenin\/","title":{"rendered":"Differentiation of spinal cord neural precursors and hippocampal neurons: a role for wnt and b-catenin"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Delia David <\/strong><\/h2>\n<p>Proper development of the nervous system requires a precise coordination of neurogenesis and neuronal morphogenesis. Neural progenitors, exposed to specific local environmental signals that regulate their proliferation and specification, give rise to neurons. Newborn neurons start extending neuronal processes that develop into a complex arbour. This step results in the formation of synapses between axons and dendrites and the assembly of functional brain networks. Among the extracellular factors that control these processes, wnts, neurotrophins (nts)  and hepatocyte growth factor (hgf) are of special interes for this work. wnts have been shown to regulate proliferation of neural precursors, neurogenesis, terminal neuronal differentiation and synaptogenesis. Classical wnt signalling involves stabilization of cytoplasmic \u00edY-catenin and regulation of transcription by lef\/tcf transcription factors. Here we demonstrated that wnt-3a and wnt-3 signalling through the canonical\/\u00edY-catenin pathway regulate neuronal differentiation (neurogenesis and neuritogenesis) of spinal cord neuronal precursors.     nts and hgf belong to different growth factor families signalling through receptor tyrosine kinase (rtk) that are important  regulators of neuron survival and differentiation. In this work we showed the involvement of \u00edY-catenin tyrosine phosphorylation downstream of nts and hgf signalling during the regulation of axon outgrowth and branching in postmitotic neurons. Nts and hgf signalling phosphorylate \u00edY-catenin at different residues (y654 and y142, respectively). Interestingly, these differential tyrosine phosphorylations target \u00edY-catenin to distinct subcellular locations and activate different downstream mechanisms (tcf-independent and dependent) to regulate axon morphogenesis.  collectively, this work highlights the importance of  \u00edY-catenin, as a signalling component of wnt-dependent and growth factor\/rtk pathways, in the control of different aspects of the neuronal differentiation.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Differentiation of spinal cord neural precursors and hippocampal neurons: a role for wnt and b-catenin<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Differentiation of spinal cord neural precursors and hippocampal neurons: a role for wnt and b-catenin <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Delia David <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Judit Herreros Danes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: loreta Medina hernandez <\/li>\n<li>teresa Iglesias vacas (vocal)<\/li>\n<li>carme Gallego gonzalez (vocal)<\/li>\n<li>soledad Alcantara horrillo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Delia David Proper development of the nervous system requires a precise coordination of neurogenesis and neuronal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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