{"id":92203,"date":"2018-03-11T10:11:11","date_gmt":"2018-03-11T10:11:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-procesamiento-e-interacciones-de-cd44-y-mt1-mmp-durante-la-invasion-tumoral\/"},"modified":"2018-03-11T10:11:11","modified_gmt":"2018-03-11T10:11:11","slug":"estudio-del-procesamiento-e-interacciones-de-cd44-y-mt1-mmp-durante-la-invasion-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-procesamiento-e-interacciones-de-cd44-y-mt1-mmp-durante-la-invasion-tumoral\/","title":{"rendered":"Estudio del procesamiento e interacciones de cd44 y mt1-mmp durante la invasi\u00f3n tumoral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Marrero Diaz <\/strong><\/h2>\n<p>La invasi\u00f3n de c\u00e9lulas tumorales es un proceso complejo y altamente organizado que implica la generaci\u00f3n de fuerzas de tracci\u00f3n a trav\u00e9s de los contactos adhesivos con las prote\u00ednas de la matriz extracelular (ecm) y la reorganizaci\u00f3n del citoesquelet o, as\u00ed como la degradaci\u00f3n de la ecm por enzimas proteol\u00edticas. Hasta ahora, el estudio de los procesos migratorios se ha realizado en su mayor parte mediante ensayos bidimensionales. Nuestro trabajo establece en primer lugar un modelo de invasi\u00f3n de  c\u00e9lulas tumorales utilizando matrices tridimensionales que mimetizan la ecm de los tejidos. Ensayos de microscop\u00eda confocal de c\u00e9lulas vivas nos han permitido llevar a cabo estudios din\u00e1micos de comportamiento celular, as\u00ed como el an\u00e1lisis de la dis tribuci\u00f3n de mol\u00e9culas implicadas en la adhesi\u00f3n celular (cd44), en reorganizaciones de citoesqueleto (erm), y en la degradaci\u00f3n de la matriz por metaloproteinasas de matriz (mmps) durante la invasi\u00f3n de c\u00e9lulas tumorales.  la mol\u00e9cula de adhesi\u00f3n cd 44 y la metaloproteinasa de matriz de tipo membrana mt1-mmp act\u00faan coordinadamente en c\u00e9lulas tumorales para promover la invasi\u00f3n celular a trav\u00e9s de un mecanismo desconocido en la actualidad. Nuestros estudios de fret han revelado por primera vez la  interacci\u00f3n \u00c2\u00bfin vivo\u00c2\u00bf entre cd44 y mt1-mmp que ocurre preferentemente en el polo posterior de c\u00e9lulas tumorales invasivas durante la liberaci\u00f3n de los contactos con la ecm en el proceso de retracci\u00f3n celular, as\u00ed como en fragmentos de membrana liber ados por la c\u00e9lula durante el proceso de invasi\u00f3n. Asimismo, un biosensor fluorescente dise\u00f1ado para monitorizar el procesamiento proteol\u00edtico de cd44 demostr\u00f3 que el corte del dominio extracelular de cd44 tiene lugar durante la retracci\u00f3n del polo t rasero de c\u00e9lulas tumorales invasivas. Adem\u00e1s, los ensayos de invasi\u00f3n mostraron que mt1-mmp media la invasi\u00f3n celular dependiente de cd44, mientras que cd44 no es esencial para que se produzca la invasi\u00f3n mediada por mt1-mmp. Estos resultados revela n el importante papel que juega mt1-mmp en el procesamiento proteol\u00edtco de cd44 durante la liberaci\u00f3n de contactos de la c\u00e9lula con la ecm en la parte posterior de la c\u00e9lula en el proceso de invasi\u00f3n tumoral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del procesamiento e interacciones de cd44 y mt1-mmp durante la invasi\u00f3n tumoral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del procesamiento e interacciones de cd44 y mt1-mmp durante la invasi\u00f3n tumoral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Marrero Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Concepcion Montoya Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda antonia Lizarbe iracheta <\/li>\n<li>alicia Garc\u00eda arroyo (vocal)<\/li>\n<li>Carlos Caba\u00f1as (vocal)<\/li>\n<li>joaqu\u00edn Teixid\u00f3 calvo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Marrero Diaz La invasi\u00f3n de c\u00e9lulas tumorales es un proceso complejo y altamente organizado que implica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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