{"id":92234,"date":"2018-03-11T10:11:11","date_gmt":"2018-03-11T10:11:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-sistema-encocannabinoide-en-la-inflamacion-del-sistema-nervioso-central-actividad-biologica-de-la-n-araquidonoildopamina\/"},"modified":"2018-03-11T10:11:11","modified_gmt":"2018-03-11T10:11:11","slug":"el-sistema-encocannabinoide-en-la-inflamacion-del-sistema-nervioso-central-actividad-biologica-de-la-n-araquidonoildopamina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cordoba\/el-sistema-encocannabinoide-en-la-inflamacion-del-sistema-nervioso-central-actividad-biologica-de-la-n-araquidonoildopamina\/","title":{"rendered":"El sistema encocannabinoide en la inflamacion del sistema nervioso central. actividad biologica de la n-araquidonoildopamina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Mar\u00eda Navarrete Rueda <\/strong><\/h2>\n<p>El enorme inter\u00e9s en el estudio del sistema cannabinoide durante los \u00faltimos a\u00f1os se debe sin duda al descrubrimiento del sistema end\u00f3geno cannabinoide. Adem\u00e1s de los receptores cannabinoides, este sistema comprende tambi\u00e9n sus ligandos end\u00f3genos (los endocannabinoides) y las prote\u00ednas para su s\u00edntesis e inactivaci\u00f3n. El sistema endocannabinoide juega un papel importante en la neuroprotecci\u00f3n, tanto en da\u00f1o neuronal agudo (lesi\u00f3n cerebral, accidente cerebrovascular y epil\u00e9psia), como en desordenes neurodegenerativos cr\u00f3nicos: esclerosis m\u00faltiple, enfermedades de parkinson, huntington y alzheimer, y esclerosis lateral amiotr\u00f3fica. Estas enfermedades neurodegenerativas van ligadas a procesos de neuroinflamaci\u00f3n. En esta tesis hemos querido estudiar la actividad biol\u00f3gica del endocannabinoide n-araquidonoildopamina (nada) en el sistema nervioso central, tomando como modelo, cultivos de c\u00e9lulas primarias de la gl\u00eda (microgl\u00eda y astrocitos), as\u00ed como en c\u00e9lulas de endotelio vascular de cerebro. Como resultado de este estudio, hemos descrito un posible papel antiinflamatorio para la n-araquidonoildopamina en el snc, mediante la inhibici\u00f3n de la enzima pges-1 microsomal responsable de la s\u00edntesis de pge2,  uno de los prostanoides m\u00e1s sintetizados en cerebro a partir del \u00e1cido araquid\u00f3nico, y al que se le ha atribuido un papel muy importante en el desarrollo de los procesos neuroinflamatorios. Por otro lado, la n-araquidonoildopamina aumenta la expresi\u00f3n de la cox-2 en c\u00e9lulas de endotelio de cerebro mediante la estabilizaci\u00f3n del arnm de cox-2, a trav\u00e9s de una v\u00eda dependiente de la mapk p38. Este aumento en la ciclooxigenasa no se traduce en una mayor producci\u00f3n de pge2 puesto que nada inhibe la enzima pges-1 microsomal. En contraposici\u00f3n a estos datos hemos encontrado una mayor producci\u00f3n en la prostaglandina pgd2 a la que se le ha atribuido un car\u00e1cter protector en cerebro en varios modelos experimentales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El sistema encocannabinoide en la inflamacion del sistema nervioso central. actividad biologica de la n-araquidonoildopamina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El sistema encocannabinoide en la inflamacion del sistema nervioso central. actividad biologica de la n-araquidonoildopamina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Mar\u00eda Navarrete Rueda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Mu\u00f1oz Blanco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Solana lara <\/li>\n<li>carmen Guaza rodriguez (vocal)<\/li>\n<li>Javier Fernandez ruiz (vocal)<\/li>\n<li>ismael Galve roperh (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Mar\u00eda Navarrete Rueda El enorme inter\u00e9s en el estudio del sistema cannabinoide durante los \u00faltimos a\u00f1os [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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