{"id":92268,"date":"2018-03-11T10:11:15","date_gmt":"2018-03-11T10:11:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-calcio-mitocondrial-en-la-neurotoxicidad-del-peptido-amiloide-y-en-la-neuroproteccion-por-anti-inflamatorios-no-esteroideos\/"},"modified":"2018-03-11T10:11:15","modified_gmt":"2018-03-11T10:11:15","slug":"papel-del-calcio-mitocondrial-en-la-neurotoxicidad-del-peptido-amiloide-y-en-la-neuroproteccion-por-anti-inflamatorios-no-esteroideos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/papel-del-calcio-mitocondrial-en-la-neurotoxicidad-del-peptido-amiloide-y-en-la-neuroproteccion-por-anti-inflamatorios-no-esteroideos\/","title":{"rendered":"Papel del calcio mitocondrial en la neurotoxicidad del p\u00e9ptido amiloide y en la neuroprotecci\u00f3n por anti-inflamatorios no esteroideos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sara Isabel Sanz Blasco <\/strong><\/h2>\n<p>La alteraci\u00f3n de la homeostasis del calcio intracelular producida en la enfermedad de alzheimer podr\u00eda ser la causa fundamental de la toxicidad del p\u00e9ptido beta amiloide (a\u00edY), pero el mecanismo es desconocido. En este trabajo se ha comprobado c\u00f3mo los olig\u00f3meros del a\u00edY 1-42, el estado de agregaci\u00f3n m\u00e1s relacionado con la p\u00e9rdida cognitiva en la ea, pero no las fibrillas del a\u00edY 1-42, inducen una entrada masiva de calcio en las neuronas, y promueven una sobrecarga del calcio mitocondrial como muestran las im\u00e1genes de bioluminiscencia de neuronas individuales que expresan la prote\u00edna aecuorina dirigida a la mitocondria. Adem\u00e1s, se ha visto que los olig\u00f3meros de a\u00edY inducen apertura del poro de transici\u00f3n de permeabilidad mitocondrial, liberaci\u00f3n de citocromo c, apoptosis y muerte celular.  se ha comprobado c\u00f3mo una despolarizaci\u00f3n parcial de la mitocondria previene la sobrecarga del calcio en la mitocondria, la liberaci\u00f3n de citocromo c y la muerte celular. En relaci\u00f3n con esto, se describe en este trabajo c\u00f3mo una serie de antiinflamatorios no esteroideos (aines), incluyendo salicilato, sulfuro de sulindac, indometacina, ibuprofeno y r-flurbiprofeno, despolarizan la mitocondria e inhiben la sobrecarga de calcio mitocondrial, la liberaci\u00f3n de citocromo c y la muerte celular inducida por los olig\u00f3meros de a\u00edY. Estos resultados indican que la sobrecarga de calcio en la mitocondria est\u00e1 directamente implicada en la neurotoxicidad inducida por los olig\u00f3meros de a\u00edY. La inhibici\u00f3n de esta sobrecarga de calcio mitocondrial proporciona un nuevo mecanismo de neuroprotecci\u00f3n por aines en la enfermedad de alzheimer.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del calcio mitocondrial en la neurotoxicidad del p\u00e9ptido amiloide y en la neuroprotecci\u00f3n por anti-inflamatorios no esteroideos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del calcio mitocondrial en la neurotoxicidad del p\u00e9ptido amiloide y en la neuroprotecci\u00f3n por anti-inflamatorios no esteroideos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sara Isabel Sanz Blasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Villalobos Jorge<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ana M\u00aa de los angeles Sanchez garcia <\/li>\n<li>joaqu\u00edn Jord\u00e1n bueso (vocal)<\/li>\n<li>Miguel \u00e1ngel Valverde de castro (vocal)<\/li>\n<li>Miguel Calero lara (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sara Isabel Sanz Blasco La alteraci\u00f3n de la homeostasis del calcio intracelular producida en la enfermedad de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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