{"id":92322,"date":"2018-03-11T10:11:19","date_gmt":"2018-03-11T10:11:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nuevos-mediadores-de-la-lesion-podocitaria-en-la-nefropata%c2%ada-diabetica\/"},"modified":"2018-03-11T10:11:19","modified_gmt":"2018-03-11T10:11:19","slug":"nuevos-mediadores-de-la-lesion-podocitaria-en-la-nefropata%c2%ada-diabetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/nefrologia\/nuevos-mediadores-de-la-lesion-podocitaria-en-la-nefropata%c2%ada-diabetica\/","title":{"rendered":"Nuevos mediadores de la lesi\u00f3n podocitaria en la nefropat\u00edadiab\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Dolores Sanchez Ni\u00f1o <\/strong><\/h2>\n<p>La nefropat\u00eda diab\u00e9tica (nd) es una de las principales complicaciones de la diabetes y la causa m\u00e1s com\u00fan de enfermedad renal en fase terminal. La progresi\u00f3n de la nd se caracteriza por la p\u00e9rdida de podocitos y de c\u00e9lulas tubulares, en asociaci\u00f3n a inflamaci\u00f3n local, dando como resultado proteinuria y p\u00e9rdida progresiva de la funci\u00f3n renal. La hiperglucemia activa mediadores secundarios que conducen a la nd. Uno de ellos es la angiotensina ii, y la intervenci\u00f3n sobre esta enlentece pero no evita, la progresi\u00f3n de la lesi\u00f3n renal. Es de gran inter\u00e9s la b\u00fasqueda de nuevas dianas donde desarrollar nuevas estrategias terap\u00e9uticas.  en esta tesis hemos analizado el transcriptoma de biopsias renales humanas con nd para identificar genes sobre-expresados con un potencial inter\u00e9s patog\u00e9nico y hemos abordado su expresi\u00f3n en la nd experimental y su funci\u00f3n en c\u00e9lulas renales cultivadas. En concreto, hemos identificado nuevos papeles de cd74, basp1 y tweak\/fn14 en el da\u00f1o renal. cd74 es un gen sobre-expresado en podocitos y c\u00e9lulas tubulares en la nd. Tanto la hiperglucemia como citoquinas inflamatorias favorecen la expresi\u00f3n de cd74. Mif act\u00faa a trav\u00e9s de cd74 y activa quinasas y la secreci\u00f3n de mediadores de inflamaci\u00f3n en podocitos y c\u00e9lulas tubulares cultivadas. Algunos de los mediadores producidos en respuesta a mif, como trail, inducen apoptosis de podocitos. Mif tambi\u00e9n induce la expresi\u00f3n de basp1 y fn14. la expresi\u00f3n de basp1 est\u00e1 aumentada en el t\u00fabulointersticio de la nd. Hemos identificado un nuevo papel de basp1 como promotor de la apoptosis de c\u00e9lulas tubulares. Est\u00edmulos letales aumentan la expresi\u00f3n de basp1 en c\u00e9lulas cultivadas, la sobre-expresi\u00f3n de basp1 promueve la apoptosis mediada por caspasas y la inhibici\u00f3n de basp1 protege de la apoptosis.  la expresi\u00f3n de tweak y fn14 est\u00e1 aumentada en nefropat\u00edas experimentales con lesi\u00f3n podocitaria. Durante el da\u00f1o glomerular los podocitos expresan fn14 y responden a tweak secretando mediadores de la inflamaci\u00f3n.  en conclusi\u00f3n, hemos identificado a cd74, basp1 y tweak\/fn14 como nuevos mediadores de la lesi\u00f3n renal, que est\u00e1n interrelacionados entre s\u00ed, y que son posibles dianas terap\u00e9uticas para la nd. Cd74 y tweak podr\u00edan contribuir de forma directa a la lesi\u00f3n subletal del podocito, y cd74, de forma indirecta a trav\u00e9s de trail y basp1, a la muerte por apoptosis de c\u00e9lulas renales. Basp1 es un nuevo inductor de apoptosis.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nuevos mediadores de la lesi\u00f3n podocitaria en la nefropat\u00edadiab\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nuevos mediadores de la lesi\u00f3n podocitaria en la nefropat\u00edadiab\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Dolores Sanchez Ni\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Ortiz Arduan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda laura Garc\u00eda bermejo <\/li>\n<li>Alberto Tejedor Jorge (vocal)<\/li>\n<li>ricardo Jos\u00e9 Bosch mart\u00ednez (vocal)<\/li>\n<li>Luisa Mar\u00eda Botella cubells (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Dolores Sanchez Ni\u00f1o La nefropat\u00eda diab\u00e9tica (nd) es una de las principales complicaciones de la diabetes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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