{"id":92347,"date":"2018-03-11T10:11:19","date_gmt":"2018-03-11T10:11:19","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/pronostico-en-el-cancer-epitelial-glandular-salival-modelizacion-de-la-supervivencia-basada-en-el-analisis-de-datos-cla%c2%adnicos-y-moleculares-e-inteligencia-artificial\/"},"modified":"2018-03-11T10:11:19","modified_gmt":"2018-03-11T10:11:19","slug":"pronostico-en-el-cancer-epitelial-glandular-salival-modelizacion-de-la-supervivencia-basada-en-el-analisis-de-datos-cla%c2%adnicos-y-moleculares-e-inteligencia-artificial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/inteligencia-artificial\/pronostico-en-el-cancer-epitelial-glandular-salival-modelizacion-de-la-supervivencia-basada-en-el-analisis-de-datos-cla%c2%adnicos-y-moleculares-e-inteligencia-artificial\/","title":{"rendered":"Pron\u00f3stico en el c\u00e1ncer epitelial glandular salival. modelizaci\u00f3n de la supervivencia basada en el an\u00e1lisis de datos cl\u00ednicos y moleculares e inteligencia artificial."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paloma Lequerica Fernandez <\/strong><\/h2>\n<p>El pron\u00f3stico de los carcinomas glandulares salivales es malo, siendo preciso realizar un tratamiento radical de los mismos para lograr su curaci\u00f3n. Estos tumores progresan de forma inexorable, siendo no obstante dif\u00edcil anticipar el pron\u00f3stico en el momento del diagn\u00f3stico por medio de variables cl\u00ednico-patol\u00f3gicas. Con la intenci\u00f3n de mejorar esta anticipaci\u00f3n pron\u00f3stica, hemos estudiado diversos marcadores biol\u00f3gicos. objetivos: determinar (1) factores pron\u00f3sticos de supervivencia espec\u00edfica y recidiva local, (2) relevancia terap\u00e9utica de e-cadherina, vegf, mmp-7,-9, y -14. (3) desarrollar un nuevo m\u00e9todo basado en t\u00e9cnicas de inteligencia artificial para predecir la progresi\u00f3n tumoral y anticipar el pron\u00f3stico. material y m\u00e9todo: este estudio se ha llevado a cabo con 66 pacientes (30 hombres y 36 mujeres) aquejados de carcinomas salivales. Se analizaron variables clinicopatol\u00f3gicas junto con la inmunoexpresi\u00f3n de e-cadherina, vegf, mmp-7,-9, y-14. Los datos fueron analizados mediante tests estad\u00edsticos cl\u00e1sicos, an\u00e1lisis de supervivencia uni y multivariables (kaplan-meier, cox) y modelos basados en splines (mars) y redes neuronales artificiales. resultados: en el an\u00e1lisis univariable numerosas variables mostraron significaci\u00f3n pron\u00f3stica, si bien, las \u00fanicas mol\u00e9culas relacionables con la supervivencia fueron la mmp-9 y el vegf. No obstante, en el an\u00e1lisis multivariable de cox, solo n, m y el grado tumoral fueron variables significativas en la determinaci\u00f3n de la supervivencia de los pacientes. Se establecieron cuatro modelos basados en splines y uno m\u00e1s mediante una red neuronal. Entre los primeros, el modelo m\u00e1s \u00fatil en su aplicaci\u00f3n est\u00e1 formado por las variables t, n, m, n\u00famero de recidivas, edad, e inmunoexpresi\u00f3n de mmp-9.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Pron\u00f3stico en el c\u00e1ncer epitelial glandular salival. modelizaci\u00f3n de la supervivencia basada en el an\u00e1lisis de datos cl\u00ednicos y moleculares e inteligencia artificial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Pron\u00f3stico en el c\u00e1ncer epitelial glandular salival. modelizaci\u00f3n de la supervivencia basada en el an\u00e1lisis de datos cl\u00ednicos y moleculares e inteligencia artificial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paloma Lequerica Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos De Vicente Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  sebasti\u00e1n L\u00f3pez-arranz arranz <\/li>\n<li>gonzalo Hern\u00e1ndez vallejo (vocal)<\/li>\n<li>joseba Santamar\u00eda zuazua (vocal)<\/li>\n<li>Jos\u00e9 Luis L\u00f3pez cedr\u00fan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paloma Lequerica Fernandez El pron\u00f3stico de los carcinomas glandulares salivales es malo, siendo preciso realizar un tratamiento 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