{"id":92401,"date":"2018-03-11T10:11:23","date_gmt":"2018-03-11T10:11:23","guid":{"rendered":""},"modified":"2018-03-11T10:11:23","modified_gmt":"2018-03-11T10:11:23","slug":"papel-de-la-vaccinia-related-kinase-1-de-caenorhabditis-elegans-en-la-embriogenesis-temprana-y-el-desarrollo-de-organos-the-role-of-caenorhabditis-elegans-vaccinia-related-kinase-1-in-early-embryogen","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/embriologia\/papel-de-la-vaccinia-related-kinase-1-de-caenorhabditis-elegans-en-la-embriogenesis-temprana-y-el-desarrollo-de-organos-the-role-of-caenorhabditis-elegans-vaccinia-related-kinase-1-in-early-embryogen\/","title":{"rendered":"Papel de la vaccinia-related kinase-1 de caenorhabditis elegans en la embriog\u00e9nesis temprana y el desarrollo de \u00f3rganos. the role of caenorhabditis elegans vaccinia-related kinase-1 in early embryogenesis and organ development"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elke Patricia Francine Klerkx <\/strong><\/h2>\n<p>Esta tesis se centra en el \u00fanico ort\u00f3logo de caenorhabditis elegans de la quinasa de mam\u00edfero vaccinia-related kinase (vrk), llamada vrk-1, una prote\u00edna muy conservada pero poco estudiada. Combinando m\u00e9todos bioqu\u00edmicos de vanguardia, de gen\u00f3mica y de biolog\u00eda celular y del desarrollo, he revelado varios papeles de la prote\u00edna quinasa vrk-1 incluyendo la identificaci\u00f3n de barrier-to-autointegration factor-1 (baf-1) como sustrato fosforilable de vrk-1. an\u00e1lisis in vivo de c. Elegans vrk-1, utilizando embriones tratados de vrk-1 (rnai), mostro que vrk-1 es esencial para la divisi\u00f3n celular y la formaci\u00f3n del envoltura nuclear (ne). La depleci\u00f3n de vrk-1 da lugar a defectos en la divisi\u00f3n celular, incluyendo cambios en la arquitectura de las estructuras de la ne. Vrk-1 se localiza en los bordes del n\u00facleo y en la cromatina de manera dependiente de la progresi\u00f3n del ciclo celular. Mis resultados han demostrado que la fosforilaci\u00f3n de baf-1 por vrk-1 juega un papel regulador esencial en la asociaci\u00f3n de baf con la cromatina y las prote\u00ednas de la membrana nuclear durante la formaci\u00f3n del ne. descubr\u00ed que vrk-1 es esencial para la formaci\u00f3n de la vulva, el utero, utse y para el desarrollo y mantenimiento de la g\u00f3nada. Vrk-1 tiene un papel esencial en la regulaci\u00f3n temporal de la invasi\u00f3n ac de la membrana bajera que separa la g\u00f3nada de la vulva. Investigaci\u00f3n de 2 efectores del medio de se\u00f1alizaci\u00f3n ras, egl-15 y egl-17, ha demostrado que vrk-1 est\u00e1 involucrado en este medio de se\u00f1alizaci\u00f3n y tambi\u00e9n he investigado la involucraci\u00f3n de vrk-1 en el medio de se\u00f1alizaci\u00f3n de smo-1. Mi hip\u00f3tesis declara que vrk-1 se expresa en las c\u00e9lulas vulva y \u00e9ste es esencial para la formaci\u00f3n de los \u00f3rganos reproductores som\u00e1ticos debido a la expresi\u00f3n de una ligand o la activaci\u00f3n de la se\u00f1alizaci\u00f3n de rtk\/ras\/mapk en las c\u00e9lulas vulva.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la vaccinia-related kinase-1 de caenorhabditis elegans en la embriog\u00e9nesis temprana y el desarrollo de \u00f3rganos. the role of caenorhabditis elegans vaccinia-related kinase-1 in early embryogenesis and organ development<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la vaccinia-related kinase-1 de caenorhabditis elegans en la embriog\u00e9nesis temprana y el desarrollo de \u00f3rganos. the role of caenorhabditis elegans vaccinia-related kinase-1 in early embryogenesis and organ development <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elke Patricia Francine Klerkx <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Peter Askjaer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro alfonso Lazo-zbikowski taracena <\/li>\n<li>marie-anne Felix (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elke Patricia Francine Klerkx Esta tesis se centra en el \u00fanico ort\u00f3logo de caenorhabditis elegans de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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