{"id":92547,"date":"2018-03-11T10:11:33","date_gmt":"2018-03-11T10:11:33","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analysis-of-kras-endosomal-traffic-and-signaling\/"},"modified":"2018-03-11T10:11:33","modified_gmt":"2018-03-11T10:11:33","slug":"analysis-of-kras-endosomal-traffic-and-signaling","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/analysis-of-kras-endosomal-traffic-and-signaling\/","title":{"rendered":"Analysis of kras endosomal traffic and signaling"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Albert Lu L\u00f3pez <\/strong><\/h2>\n<p>En este trabajo hemos estudiado los mecanismos que regulan la endocitosis de la oncoprote\u00edna kras. Hemos visto que la estimulaci\u00f3n con egf (factor de crecimiento epid\u00e9rmico) induce la endocitosis de kras a trav\u00e9s de ccps (\u00abclathrin coated pits). Una vez endocitada, kras es transportada hacia el compartimiento endosomal temprano y desde all\u00ed sigue la ruta endosomal hacia los endosomas tard\u00edos. Una vez en el compartimiento endosomal tard\u00edo, mediante el uso de t\u00e9cnicas de fret intramolecular con la sonda raichu-kras, monitorizamos la cin\u00e9tica de activaci\u00f3n de kras in vivo en este compartimiento celular. Tambi\u00e9n se estudi\u00f3 la degradaci\u00f3n de kras a nivel lisosomal. Finalmente analizamos la v\u00eda de se\u00f1alizaci\u00f3n de las mapk inducida por kras en endosomas tard\u00edos positivos para p14 y mp1. Se observ\u00f3 que la inhibici\u00f3n lisosomal produce una se\u00f1alizaci\u00f3n sostenida probablemente a expensas de inhibir la degradaci\u00f3n de kras y otras mol\u00e9culas como el receptor de egf. Estos resultados indican que los endosomas tard\u00edos constituyen una plataforma de se\u00f1alizaci\u00f3n de kras y aportan nuevos datos sobre el tr\u00e1fico y la regulaci\u00f3n de esta prote\u00edna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analysis of kras endosomal traffic and signaling<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analysis of kras endosomal traffic and signaling <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Albert Lu L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/03\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oriol Bachs Valldeneu<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gustavo Egea guri <\/li>\n<li>ian Prior (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Albert Lu L\u00f3pez En este trabajo hemos estudiado los mecanismos que regulan la endocitosis de la oncoprote\u00edna [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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