{"id":9269,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/sintesis-y-estudio-estructural-de-derivados-del-sistema-de-3-azabiciclo3-3-1nonano-como-antagonistas-potenciales-de-receptores-gaba\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"sintesis-y-estudio-estructural-de-derivados-del-sistema-de-3-azabiciclo3-3-1nonano-como-antagonistas-potenciales-de-receptores-gaba","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-y-estudio-estructural-de-derivados-del-sistema-de-3-azabiciclo3-3-1nonano-como-antagonistas-potenciales-de-receptores-gaba\/","title":{"rendered":"Sintesis y estudio estructural de derivados del sistema de 3-azabiciclo(3.3.1)nonano como antagonistas potenciales de receptores gaba."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nadine Smeyers Tamargo <\/strong><\/h2>\n<p>Este trabajo se inscribe en el marco de investigacion de departamento de q. Organica de la universidad de alcala de henares sobre compuestos potencialmente activos a nivel del sistema nervioso central.  con el proposito de encontrar nuevos compuestos con accion antagonista de los receptores gaba y\/o gabab se ha llevado a cabo la sintesis y el estudio estructural de una serie de esteres derivados del ac.  2,4-difenil-9-beta-hidroxi-3-metil-3-azabiciclo(3.3.1) nonan-9-alfa-carboxilico, un analogo rigido del ac.  -aminobutinico (gaba).  la sintesis se abordo comenzando por la preparacion de la 2,4-diaril-3-azabiciclo (3.3.1)nonan-9-onas, cuya transformacion en los correspondientes alfa-hidroxicarbonitrilos y posterior hidrolisis acida conduce al alfa-hidroxi-acido precursor de las series de alfa-aciloxiacidos y alfa-hidroxiesteres derivados del sistema de 2,4-difenil-3- metil-3-azabiciclo(3.3.1) nonano sintetizados.  el estudio estructural se ha realizado mediante: 1) difraccion de rayos x en el caso de la 2,4-difenil-3- metil-3-azabiciclo(3.3.1)nonan-9-ona;2) analisis detallado de los espectros de rmn de 1h y 13c, utilizando tecnicas bidimensionales y experimentos de doble resonancia y 3) aplicacion de modelizacion molecular con ayuda de metodos semi-empiricos mecanocuanticos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y estudio estructural de derivados del sistema de 3-azabiciclo(3.3.1)nonano como antagonistas potenciales de receptores gaba.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y estudio estructural de derivados del sistema de 3-azabiciclo(3.3.1)nonano como antagonistas potenciales de receptores gaba. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nadine Smeyers Tamargo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Arias Perez M. Selma<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Julio \u00e1lvarez-builla G\u00f3mez <\/li>\n<li>Mart\u00edn Mart\u00ednez Ripoll (vocal)<\/li>\n<li>Francisco Zaragoza Garcia (vocal)<\/li>\n<li>Alfonso Hernandez Laguna (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nadine Smeyers Tamargo Este trabajo se inscribe en el marco de investigacion de departamento de q. Organica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,1412,1648,17,416],"tags":[21868,6644,4080,762,12951,31887],"class_list":["post-9269","post","type-post","status-publish","format-standard","hentry","category-alcala","category-compuestos-heterociclicos","category-estructura-de-moleculas-organicas","category-quimica","category-quimica-organica","tag-alfonso-hernandez-laguna","tag-arias-perez-m-selma","tag-francisco-zaragoza-garcia","tag-julio-alvarez-builla-gomez","tag-martin-Martinez-ripoll","tag-nadine-smeyers-tamargo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/9269","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=9269"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/9269\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=9269"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=9269"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=9269"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}