{"id":92745,"date":"2009-03-04T00:00:00","date_gmt":"2009-03-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/carcinoma-infiltrante-de-mama-valoracion-pronostica-de-marcadores-cla%c2%adnico-patologicos-y-biologicos\/"},"modified":"2009-03-04T00:00:00","modified_gmt":"2009-03-04T00:00:00","slug":"carcinoma-infiltrante-de-mama-valoracion-pronostica-de-marcadores-cla%c2%adnico-patologicos-y-biologicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia\/carcinoma-infiltrante-de-mama-valoracion-pronostica-de-marcadores-cla%c2%adnico-patologicos-y-biologicos\/","title":{"rendered":"Carcinoma infiltrante de mama: valoraci\u00f3n pron\u00f3stica de marcadores cl\u00ednico-patol\u00f3gicos y biol\u00f3gicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Duran Garcia <\/strong><\/h2>\n<p>Objetivos: -determinar el valor pron\u00f3stico de los marcadores clinicopatol\u00f3gicos cl\u00e1sicos como la edad, tama\u00f1o tumoral, grado histol\u00f3gico, estado de los ganglios linf\u00e1ticos axilares, invasi\u00f3n vascular y necrosis tumoral, as\u00ed como de los marcadores biol\u00f3gicos, receptores de estradiol y progesterona, actividad proliferativa con ki-67, prote\u00ednas bcl2, p53 y c-erbb-2, en el carcinoma ductal infiltrante de mama . -clasificar los casos con ganglios negativos en dos grupos, de bajo grado y alto grado histol\u00f3gico, discriminando los casos mediante la actividad proliferativa y establecer su significado pron\u00f3stico. -determinar el valor predictivo de las variables cl\u00e1sicas  y las biol\u00f3gicas, en relaci\u00f3n con la   supervivencia libre de enfermedad y global, mediante el an\u00e1lisis discriminante. -comparar el valor predictivo de las variables cl\u00e1sicas en relaci\u00f3n con las biol\u00f3gicas en cuanto a la supervivencia libre de enfermedad y la supervivencia global. conclusiones: -las t\u00e9cnicas de an\u00e1lisis univariable y multivariable son \u00fatiles para determinar el valor pron\u00f3stico y la importancia relativa de los marcadores clinicopatolog\u00edcos y biol\u00f3gicos en el carcinoma ductal infiltrante de mama y discriminangrupos de buen y mal pron\u00f3stico. -los casos de bajo grado histol\u00f3gico, presentan una supervivencia libre de enfermedad y global mayor que los casos de alto grado histol\u00f3gico.  -las t\u00e9cnicas de an\u00e1lisis discriminante permiten llegar a predecir de forma correcta  el 97% de la supervivencia global en el grupo de pacientes con ganglios positivos y el 86%  de la supervivencia global en el grupo de los pacientes con ganglios negativos. -las variables  cl\u00ednico- patol\u00f3gicas  muestran un valor predictivo, en relaci\u00f3n con la supervivencia libre de enfermedad y global, mucho mayor que las variables biol\u00f3gicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Carcinoma infiltrante de mama: valoraci\u00f3n pron\u00f3stica de marcadores cl\u00ednico-patol\u00f3gicos y biol\u00f3gicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Carcinoma infiltrante de mama: valoraci\u00f3n pron\u00f3stica de marcadores cl\u00ednico-patol\u00f3gicos y biol\u00f3gicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Duran Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Ignacio Aranda L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Lerma puertas <\/li>\n<li>encarnacion Adrover cebrian (vocal)<\/li>\n<li>laia Vernet vegue (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Duran Garcia Objetivos: -determinar el valor pron\u00f3stico de los marcadores clinicopatol\u00f3gicos cl\u00e1sicos como la edad, tama\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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