{"id":92752,"date":"2009-03-04T00:00:00","date_gmt":"2009-03-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-reguladores-de-rho-gtpasas-rgf1p-y-rgf2p-en-el-control-de-la-integridad-y-la-polaridad-en-schizosaccharomyces-pombe\/"},"modified":"2009-03-04T00:00:00","modified_gmt":"2009-03-04T00:00:00","slug":"papel-de-los-reguladores-de-rho-gtpasas-rgf1p-y-rgf2p-en-el-control-de-la-integridad-y-la-polaridad-en-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/levaduras\/papel-de-los-reguladores-de-rho-gtpasas-rgf1p-y-rgf2p-en-el-control-de-la-integridad-y-la-polaridad-en-schizosaccharomyces-pombe\/","title":{"rendered":"Papel de los reguladores de rho-gtpasas, rgf1p y rgf2p, en el control de la integridad y la polaridad en schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Garcia Rodriguez <\/strong><\/h2>\n<p>Las c\u00e9lulas de schizosaccharmomyces pombe presentan una forma cil\u00edndrica y crecen por los polos hasta alcanzar un tama\u00f1o determinado, entonces se dividen mediante la formaci\u00f3n de un septo transversal en la regi\u00f3n media de la c\u00e9lula, que separa a las dos c\u00e9lulas hijas. En cada uno de estos estados de polarizaci\u00f3n, la s\u00edntesis de nueva pared celular es necesaria para mantener tanto la forma como la integridad de la c\u00e9lula.  en nuestro grupo estudiamos la regulaci\u00f3n de la s\u00edntesis del (1,3)-glucano, que es el componente mayoritario de la pared. La enzima encargada de la bios\u00edntesis de este pol\u00edmero es la (1,3)-gluc\u00e1n sintasa (gs) que es una enzima multim\u00e9rica formada por un componente catal\u00edtico y un componente regulador (la gtpasa rho1p). hemos identificado un nuevo gef (guanine nucleotide exchange factor) llamado rgf1p que activa espec\u00edficamente a rho1p durante el crecimiento polarizado. Las c\u00e9lulas rgf1 se lisan por uno de los polos, con un fenotipo similar a las c\u00e9lulas con bajos niveles de rho1p. Adem\u00e1s, los mutantes rgf1 presentan un defecto en la reorganizaci\u00f3n de la actina necesaria para la transici\u00f3n del crecimiento monopolar a bipolar. Por lo tanto, rgf1p podr\u00eda coordinar la deposici\u00f3n de actina con la bios\u00edntesis de la pared celular, permitiendo a las c\u00e9lulas remodelar su pared sin riesgo de ruptura. Por otro lado, rgf1p es un componente de la cascada de mapks necesaria para el mantenimiento de la integridad, y es esencial para transmitir esta se\u00f1al en respuesta a cambios osm\u00f3ticos y da\u00f1os en la pared celular. otro gef estudiado en este trabajo es rgf2p, que es un activador de rho1p esencial durante el proceso de esporulaci\u00f3n, ya que en su ausencia las ascosporas son inviables. Esta prote\u00edna participa en la activaci\u00f3n de la gluc\u00e1n sintasa durante la formaci\u00f3n de la pared de las esporas. Durante el crecimiento vegetativo comparte un papel esencial con rgf1p, posiblemente como activadores de la gtpasa rho1p.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los reguladores de rho-gtpasas, rgf1p y rgf2p, en el control de la integridad y la polaridad en schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los reguladores de rho-gtpasas, rgf1p y rgf2p, en el control de la integridad y la polaridad en schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Garcia Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Yolanda Sanchez Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Rodr\u00edguez v\u00e1zquez de aldana <\/li>\n<li>Mar\u00eda  angeles De la torre ruiz (vocal)<\/li>\n<li>Rafael Rodr\u00edguez daga (vocal)<\/li>\n<li>eduardo Antonio Espeso fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Garcia Rodriguez Las c\u00e9lulas de schizosaccharmomyces pombe presentan una forma cil\u00edndrica y crecen por los polos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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