{"id":92774,"date":"2018-03-11T10:11:53","date_gmt":"2018-03-11T10:11:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/acilacion-de-protea%c2%adnas-caracterizacion-de-la-palmitoil-transferasa-humana-dhhc6\/"},"modified":"2018-03-11T10:11:53","modified_gmt":"2018-03-11T10:11:53","slug":"acilacion-de-protea%c2%adnas-caracterizacion-de-la-palmitoil-transferasa-humana-dhhc6","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/acilacion-de-protea%c2%adnas-caracterizacion-de-la-palmitoil-transferasa-humana-dhhc6\/","title":{"rendered":"Acilaci\u00f3n de prote\u00ednas: caracterizaci\u00f3n de la palmitoil-transferasa   humana dhhc6"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Corral Escariz <\/strong><\/h2>\n<p>Null la palmitoilaci\u00f3n  de prote\u00ednas es una modificaci\u00f3n postraduccional que, debido a su car\u00e1cter reversible, permite regular de forma din\u00e1mica la localizaci\u00f3n y actividad de las prote\u00ednas en la c\u00e9lula. En la presente tesis se ha estudiado el papel de la  palmitoilaci\u00f3n tomando como modelo la \u00f3xido n\u00edtrico sintasa endotelial (enos) y se ha profundizado en la caracterizaci\u00f3n de dhhc6, miembro de una familia de prote\u00ednas con actividad palmitoil-transferasa. en primer lugar, se dise\u00f1aron quimeras amino- terminales de la enos fusionadas a gfp y se analiz\u00f3 su asociaci\u00f3n a membranas en general y a subdominios de baja densidad en particular en funci\u00f3n de su grado de acilaci\u00f3n. Asimismo, se determin\u00f3 que la enos se palmitoila en su tr\u00e1nsito hacia la memb rana plasm\u00e1tica siendo dicha palmitoilaci\u00f3n parcialmente inhibida por drogas que afectan a la integridad del aparato de golgi. en la segunda parte del trabajo se describi\u00f3 la miristoilaci\u00f3n y palmitoilaci\u00f3n de dhhc6, as\u00ed como su localizaci\u00f3n subcelul ar, asociaci\u00f3n a membrana y topolog\u00eda. Se estudi\u00f3 la actividad palmitoil-transferasa de dhhc6 sobre una colecci\u00f3n de prote\u00ednas palmitoiladas de diversos tipos, encontr\u00e1ndose que h-ras era un sustrato de la enzima. La palmitoilaci\u00f3n de h-ras por parte  de dhhc6 result\u00f3 ser dependiente de la acilaci\u00f3n de \u00e9sta, y conduc\u00eda a una mayor asociaci\u00f3n de h-ras a membrana, as\u00ed como a un aumento en su capacidad de unir gtp y activar a sus efectores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Acilaci\u00f3n de prote\u00ednas: caracterizaci\u00f3n de la palmitoil-transferasa   humana dhhc6<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Acilaci\u00f3n de prote\u00ednas: caracterizaci\u00f3n de la palmitoil-transferasa   humana dhhc6 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Corral Escariz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ignacio Rodr\u00edguez Crespo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: inmaculada Navarro l\u00e9rida <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Corral Escariz Null la palmitoilaci\u00f3n de prote\u00ednas es una modificaci\u00f3n postraduccional que, debido a su car\u00e1cter [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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