{"id":92804,"date":"2018-03-11T10:11:59","date_gmt":"2018-03-11T10:11:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-anti-vih-in-vitro-de-especies-de-la-tribu-anthemideaeasteraceae-aislamiento-de-principios-activos\/"},"modified":"2018-03-11T10:11:59","modified_gmt":"2018-03-11T10:11:59","slug":"actividad-anti-vih-in-vitro-de-especies-de-la-tribu-anthemideaeasteraceae-aislamiento-de-principios-activos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/actividad-anti-vih-in-vitro-de-especies-de-la-tribu-anthemideaeasteraceae-aislamiento-de-principios-activos\/","title":{"rendered":"Actividad anti-vih in vitro de especies de la tribu anthemideae(asteraceae): aislamiento de principios activos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruben Martin Lazaro <\/strong><\/h2>\n<p>Null el objetivo principal de esta tesis doctoral es el aislamiento, identificaci\u00f3n, determinaci\u00f3n de  actividad y mecanismo de acci\u00f3n de compuestos activos anti vih a partir de un fraccionamiento biodirigido  a partir de plantas de la familia asteraceae.  Las especies vegetales que mejores resultados de actividad antiviral han demostrado tener en este screening han sido artemisia campestris subsp. Glutinosa, achillea ageratum, achillea odorata, serratula flavescens, andryala integrifolia y coleosteph us myconis. Todas ellas podr\u00edan ser especies interesantes a partir de las cuales iniciar la separaci\u00f3n de los principios activos responsables de la actividad, centr\u00e1ndonos en esta tesis en el extracto alcoh\u00f3lico de artemisia campestris subsp. Glutino sa. utilizando las t\u00e9cnicas cromatogr\u00e1ficas adecuadas, hemos fraccionado secuencialmente el extracto, con paralelo seguimiento de la actividad anti-vih in vitro, logrando aislar tres compuestos activos: cm3r, diaion 1819 y diaion 1819ii.  utilizando las t\u00e9cnicas espectrosc\u00f3picas adecuadas, se identifican estructuralmente estos tres principios activos: cm3r corresponde a 5,7,8-trihidroxi-4\u00c2\u00bf-metoxi flavanona, diaion 1819 con 5,7,8-trihidroxi-3\u00c2\u00bf-cloro-4\u00c2\u00bf-metoxi flavanona y diaion 1819ii con 5, 7, 8 -trihidroxi-3\u00c2\u00bf-(6\u00c2\u00bf\u00c2\u00bf, 3\u00c2\u00bf\u00c2\u00bf\u00c2\u00bf-dicloro-5\u00c2\u00bf\u00c2\u00bf, 7\u00c2\u00bf\u00c2\u00bf-dihidroxi-4\u00c2\u00bf\u00c2\u00bf\u00c2\u00bf,5\u00c2\u00bf\u00c2\u00bf\u00c2\u00bf-dimetoxi flavanona)-4\u00c2\u00bf-metoxi  flavanona. todos los compuestos aislados demuestran tener actividad anti vih, sin afectar a la entrada del virus, inhibiendo la transcriptasa inversa. Asimi smo, carecen de citotoxicidad a las concentraciones ensayadas. por los estudios de relaci\u00f3n estructura actividad, se postula que no es necesaria la presencia del doble enlace en 2-3 y s\u00ed lo son las sustituciones en 3\u00c2\u00bf y 4\u00c2\u00bf y las hidroxilaciones en 5 y 7.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Actividad anti-vih in vitro de especies de la tribu anthemideae(asteraceae): aislamiento de principios activos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Actividad anti-vih in vitro de especies de la tribu anthemideae(asteraceae): aislamiento de principios activos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruben Martin Lazaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jose Abad Martinez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: sagrario (secretario) Mart\u00edn-arag\u00f3n \u00e1lvarez <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruben Martin Lazaro Null el objetivo principal de esta tesis doctoral es el aislamiento, identificaci\u00f3n, determinaci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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