{"id":92898,"date":"2018-03-11T10:12:03","date_gmt":"2018-03-11T10:12:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analysis-of-human-genetic-variation-in-candidate-genes-under-positive-selection-on-the-human-lineage\/"},"modified":"2018-03-11T10:12:03","modified_gmt":"2018-03-11T10:12:03","slug":"analysis-of-human-genetic-variation-in-candidate-genes-under-positive-selection-on-the-human-lineage","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-humana\/analysis-of-human-genetic-variation-in-candidate-genes-under-positive-selection-on-the-human-lineage\/","title":{"rendered":"Analysis of human genetic variation in candidate genes under positive selection on the human lineage"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andr\u00e9s Moreno Estrada <\/strong><\/h2>\n<p>La selecci\u00f3n natural ha moldeado de forma importante la variaci\u00f3n gen\u00e9tica humana, por lo que encontrar variantes que hayan sido seleccionadas positivamente puede dar indicios acerca de los genes que determinan la diversidad fenot\u00edpica humana. En este trabajo comparamos los genes del genoma humano, del chimpanc\u00e9 y de varias especies cercanamente emparentadas para detectar aquellos genes bajo selecci\u00f3n positiva en el linaje humano, y posteriormente evaluar la variaci\u00f3n intraespec\u00edfica en un subconjunto de genes con la intenci\u00f3n de buscar eventos de selecci\u00f3n reciente en poblaciones humanas de todo el mundo. Nuestros resultados sugieren que la mayor\u00eda de genes implicados en eventos selectivos durante la evoluci\u00f3n temprana del hombre no son los mismos que aquellos involucrados en adaptaciones humanas recientes, lo que implica la existencia de diferentes presiones selectivas a lo largo de las distintas etapas de la historia evolutiva humana. Tambi\u00e9n encontramos tres regiones gen\u00f3micas con evidencias de selecci\u00f3n positiva reciente, las cuales fueron analizadas en profundidad para proponer posibles dianas de selecci\u00f3n y discutir las presiones selectivas subyacentes en cada caso.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analysis of human genetic variation in candidate genes under positive selection on the human lineage<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analysis of human genetic variation in candidate genes under positive selection on the human lineage <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andr\u00e9s Moreno Estrada <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Elena Bosch Fust\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: \u00f3scar Lao grueso <\/li>\n<li>sebastian e Ramos onsins (vocal)<\/li>\n<li>carles Lalueza fox (vocal)<\/li>\n<li>leonardo Arbiza brustin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Moreno Estrada La selecci\u00f3n natural ha moldeado de forma importante la variaci\u00f3n gen\u00e9tica humana, por lo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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