{"id":92939,"date":"2018-03-11T10:12:08","date_gmt":"2018-03-11T10:12:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-sa%c2%adntesis-de-las-fibras-elasticas-arteriales\/"},"modified":"2018-03-11T10:12:08","modified_gmt":"2018-03-11T10:12:08","slug":"regulacion-de-la-sa%c2%adntesis-de-las-fibras-elasticas-arteriales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/regulacion-de-la-sa%c2%adntesis-de-las-fibras-elasticas-arteriales\/","title":{"rendered":"Regulaci\u00f3n de la s\u00edntesis de las fibras el\u00e1sticas arteriales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Severin Slove <\/strong><\/h2>\n<p>Esta tesis se inserta en un tema general de investigaci\u00f3n que consiste en estudiar la s\u00edntesis, y su regulaci\u00f3n, de los componentes de la pared vascular en condiciones fisiol\u00f3gicas y patol\u00f3gicas. En algunas patolog\u00edas, y durante el envejecimiento, la calidad y\/o la cantidad de fibras el\u00e1sticas de la pared arterial son disminuidas. Por lo cual, queremos comprender m\u00e1s la regulaci\u00f3n de la s\u00edntesis de estas fibras. La combinaci\u00f3n de nuestras investigaciones gen\u00f3micas con la t\u00e9cnica qtl (\u00abquantitative trait loci\u00bb) por una parte, y transcript\u00f3mica con los chips de adn por otra, nos permiti\u00f3 seleccionar en la aorta de rata varios genes potencialmente candidatos. Bas\u00e1ndonos en estos resultados y en la literatura, decidimos estudiar en prioridad la regulaci\u00f3n de la s\u00edntesis de la fibras el\u00e1sticas arteriales por el potasio (k+) y el calcio (ca2+). Con experiencias de farmacolog\u00eda celular e in vivo en la rata, hemos demostrado que los abridores de canales de potasio estimulan esta s\u00edntesis y que el aumento de la cantidad del arnm de la tropoelastina (arnme) est\u00e1 debido a un aumento de la transcripci\u00f3n del gen de la elastina y de la estabilidad de los arnme. Proponemos tambi\u00e9n que la regulaci\u00f3n de la transcripci\u00f3n del gen de la elastina, por k+ y ca2+, pasa por las vias de se\u00f1alizaci\u00f3n celulares siguientes: k+-ca2+-calmoduline-erk1\/2-complejo fra1\/c-jun et k+-ca2+- calmoduline-erk1\/2-elk1-complejo c-fos\/c-jun.   conocer las vias de se\u00f1alizaci\u00f3n celulares permitir\u00e1 dirigir m\u00e1s precisamente terapias, a fin de rectificar un d\u00e9ficit de elastina en patolog\u00edas vasculares como la aterosclerosis, el s\u00edndrome de williams y beuren, y tambi\u00e9n, porque no, en el envejecimiento vascular y cut\u00e1neo. Por \u00faltimo, la busqueda de genes candidatos regulando la s\u00edntesis de los componentes de la matriz extracelular, empezada ya hace m\u00e1s de 10 a\u00f1os por nuestro equipo de investigaci\u00f3n, permitir\u00e1 quiz\u00e1 encontrar otras prote\u00ednas reguladoras y tantos objetivos terap\u00e9uticos potenciales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la s\u00edntesis de las fibras el\u00e1sticas arteriales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la s\u00edntesis de las fibras el\u00e1sticas arteriales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Severin Slove <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marie Paule Jacob<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jean-jacques (secretario) Mercader <\/li>\n<li>gilles Faury (vocal)<\/li>\n<li>Juan  Manuel Bell\u00f3n caneiro (vocal)<\/li>\n<li>laurent Debelle (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Severin Slove Esta tesis se inserta en un tema general de investigaci\u00f3n que consiste en estudiar la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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