{"id":92982,"date":"2018-03-11T10:12:13","date_gmt":"2018-03-11T10:12:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/participacion-de-los-linfocitos-t-cd4-cd28-en-la-patogenia-de-la-esclerosis-multiple\/"},"modified":"2018-03-11T10:12:13","modified_gmt":"2018-03-11T10:12:13","slug":"participacion-de-los-linfocitos-t-cd4-cd28-en-la-patogenia-de-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/participacion-de-los-linfocitos-t-cd4-cd28-en-la-patogenia-de-la-esclerosis-multiple\/","title":{"rendered":"Participaci\u00f3n de los linfocitos t cd4+ cd28- en la patogenia de la esclerosis m\u00faltiple."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jes\u00fas Pinto Medel <\/strong><\/h2>\n<p>La em es una enfermedad presumiblemente autoinmune, caracterizada por inflamaci\u00f3n, desmielinizaci\u00f3n y da\u00f1o axonal; en su patogenia tienen un papel central los linfocitos t, iniciando y potenciando la propagaci\u00f3n de la enfermedad. en esta tesis se plante\u00f3 la caracterizaci\u00f3n fenot\u00edpica de las c\u00e9lulas t cd4 que participan en la patogenia de la em y para ello se caracteriz\u00f3 fenot\u00edpicamente, analizado la expresi\u00f3n de marcadores de activaci\u00f3n, regulaci\u00f3n inmune, apoptosis, mol\u00e9culas de adhesi\u00f3n, t\u00edpicos de c\u00e9lulas nk, las subpoblaciones celulares t cd4 +cd28- y t cd4+ cd28+ de sangre perif\u00e9rica, tanto en pacientes con em como en sujetos sanos y se caracteriz\u00f3 la producci\u00f3n de citoquinas y marcadores de citotoxicidad en ambas subpoblaciones. Adem\u00e1s tambi\u00e9n se quiso valorar el efecto inmunomodulador del primer a\u00f1o de tratamiento con ifn-\u00edY sobre la expresi\u00f3n de todas los mol\u00e9culas analizadas en el estudio transversal en ambas subpoblaciones celulares. Y por \u00faltimo se quiso demostrar, in vitro, que esta subpoblad\u00f3n celular t cd4+cd28-, a pesar de ser considerada como inmunol\u00f3gicamente senescente mantiene su capacidad proliferativa frente a ant\u00edgenos de la mielina. la suma de todos los hallazgos obtenidos en esta tesis sugiere que la subpoblad\u00f3n t cd4+cd28- est\u00e1 participando activamente en los mecanismos patog\u00e9nicos subyacentes en la esclerosis m\u00faltiple y que el tratamiento inmunomodulador con ifn-b s\u00f3lo es capaz de disminuir transitoriamente su estado de activaci\u00f3n y de forma continua la expresi\u00f3n de cd57 y la capacidad de s\u00edntesis de citoquinas proinflamatorias (promoviendo la producci\u00f3n de il4), pero no es capaz de modular a la baja de forma permanente la expresi\u00f3n del resto de los marcadores adquiridos por esta subpoblaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Participaci\u00f3n de los linfocitos t cd4+ cd28- en la patogenia de la esclerosis m\u00faltiple.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Participaci\u00f3n de los linfocitos t cd4+ cd28- en la patogenia de la esclerosis m\u00faltiple. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jes\u00fas Pinto Medel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Oscar Fernandez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fuencisla Matesanz del barrio <\/li>\n<li>lina Mayorga mayorga (vocal)<\/li>\n<li>david Otaegui bichot (vocal)<\/li>\n<li>victoria eugenia Fern\u00e1ndez s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jes\u00fas Pinto Medel La em es una enfermedad presumiblemente autoinmune, caracterizada por inflamaci\u00f3n, desmielinizaci\u00f3n y da\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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