{"id":92985,"date":"2018-03-11T10:12:13","date_gmt":"2018-03-11T10:12:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-balance-de-proliferacion-apoptosis-de-las-celulas-beta-pancreaticas-murinas-en-respuesta-a-citoquinas-proinflamatorias-implicadas-en-la-patogenia-de-la-diabetes-mellitus-tipo-1\/"},"modified":"2018-03-11T10:12:13","modified_gmt":"2018-03-11T10:12:13","slug":"estudio-del-balance-de-proliferacion-apoptosis-de-las-celulas-beta-pancreaticas-murinas-en-respuesta-a-citoquinas-proinflamatorias-implicadas-en-la-patogenia-de-la-diabetes-mellitus-tipo-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-animal\/estudio-del-balance-de-proliferacion-apoptosis-de-las-celulas-beta-pancreaticas-murinas-en-respuesta-a-citoquinas-proinflamatorias-implicadas-en-la-patogenia-de-la-diabetes-mellitus-tipo-1\/","title":{"rendered":"Estudio del balance de proliferaci\u00f3n-apoptosis de las c\u00e9lulas beta pancre\u00e1ticas murinas en respuesta a citoquinas proinflamatorias implicadas en la patogenia de la diabetes mellitus tipo 1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Alejandro Blandino Rosano <\/strong><\/h2>\n<p>Las citoquinas proinflamator\u00edas (tnf-alfa, it 1-beta e len-gamma) est\u00e1n presentes en el proceso de insulitis y desencadenan el proceso de apoptosis de la c\u00e9lula beta. &#8211; se desconocen en profundidad los mecanismos de la proliferaci\u00f3n de las c\u00e9lulas beta de islotes en esta fase precl\u00ednica. el \u00f3xido n\u00edtrico se halla relacionado con la pres\u00e9ncia de citoquinas, que inhibe la proliferaci\u00f3n en otros sistemas. glp- 1 mejora la supervivencia y protege de la apoptosis a los islotes pancre\u00e1ticos en diferentes condiciones. hip\u00f3tesis: 1) las citoquinas proinflamatorias, junto a la glucosa en una concentraci\u00f3n subt\u00f3xica podr\u00edan tener efe\u00e1tos sin\u00e9rgicos .Sobre la ap\u00f3ptosis de la c\u00e9lula beta. 2) las citoquinas proinilamatorias tienen un efecto directo sobre la proliferaci\u00f3n de las c\u00e9lulas beta, que se ejerce a trav\u00e9s de las principales v\u00edas de supervivencia y proliferaci\u00f3n. Para demostrar la veracidad o falsedad de estas hip\u00f3tesis, hemos abordado este trabajo con los siguientes objetivos: 1. Estudiar los efectos de la conce\u00f1traci\u00f3n subt\u00f3xica de glucosa sobre la apoptosis de las c\u00e9lulas beta de los islotes pancre\u00e1ticos<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del balance de proliferaci\u00f3n-apoptosis de las c\u00e9lulas beta pancre\u00e1ticas murinas en respuesta a citoquinas proinflamatorias implicadas en la patogenia de la diabetes mellitus tipo 1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del balance de proliferaci\u00f3n-apoptosis de las c\u00e9lulas beta pancre\u00e1ticas murinas en respuesta a citoquinas proinflamatorias implicadas en la patogenia de la diabetes mellitus tipo 1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Alejandro Blandino Rosano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/04\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Aguilar Diosdado<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Juan Vallo  de castro <\/li>\n<li>david Cano gonz\u00e1lez (vocal)<\/li>\n<li>Mar\u00eda asunci\u00f3n Mart\u00ednez brocca (vocal)<\/li>\n<li>irene Cozar castellano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Alejandro Blandino Rosano Las citoquinas proinflamator\u00edas (tnf-alfa, it 1-beta e len-gamma) est\u00e1n presentes en el proceso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1506,851,675],"tags":[37928,43487,1740,1640,192176,192177],"class_list":["post-92985","post","type-post","status-publish","format-standard","hentry","category-cadiz","category-endocrinologia","category-fisiologia-animal","tag-david-cano-gonzalez","tag-irene-cozar-castellano","tag-jose-juan-vallo-de-castro","tag-manuel-aguilar-diosdado","tag-manuel-alejandro-blandino-rosano","tag-maria-asuncion-Martinez-brocca"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/92985","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=92985"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/92985\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=92985"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=92985"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=92985"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}