{"id":93232,"date":"2009-11-05T00:00:00","date_gmt":"2009-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/celecoxib-y-capecitabina-en-el-tratamiento-de-cancer-de-pancreas-experimental\/"},"modified":"2009-11-05T00:00:00","modified_gmt":"2009-11-05T00:00:00","slug":"celecoxib-y-capecitabina-en-el-tratamiento-de-cancer-de-pancreas-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-abdominal\/celecoxib-y-capecitabina-en-el-tratamiento-de-cancer-de-pancreas-experimental\/","title":{"rendered":"Celecoxib y capecitabina en el tratamiento de cancer de pancreas experimental"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alvaro Arjona Sanchez <\/strong><\/h2>\n<p>En el c\u00e1ncer de p\u00e1ncreas la supervivencia es muy limitada y hoy en d\u00eda se ha demostrado que la principal terapia es la resecci\u00f3n quir\u00fargica, prestando mayor atenci\u00f3n al desarrollo de terapias adyuvantes. El estr\u00e9s oxidativo y la angiog\u00e9nesis son mecanismos patog\u00e9nicos en el c\u00e1ncer de p\u00e1ncreas. La cox 2 se encuentra involucrada en ambos, por lo que el celecoxib, un inhibidor de la cox 2, act\u00faa directamente sobre estos mecanismos. El prop\u00f3sito de nuestro estudio es evaluar el efecto del celecoxib s\u00f3lo y asociado a un quimioter\u00e1pico de nueva aparici\u00f3n (capecitabina) en el c\u00e1ncer de p\u00e1ncreas experimental. Material y m\u00e9todos: estudio experimental en el que se reunieron 50  ejemplares de hamster sirio machos. Se dividieron en 5 grupos ( 1-control, 2-bop, 3-celecoxib en tratamiento, 4-capecitabina en tratamiento y 5- combinado de celecoxib y capecitabina). Se administr\u00f3 en todos los grupos a excepci\u00f3n del grupo control, el n-nitrosobis (2 oxo) propil-amina (bop) a dosis de 10 mg\/kg durante  12 semanas. La terapia fue administrada en las 12 semanas siguientes,  celecoxib por v\u00eda oral a dosis de 1500 ppm\/24h y capacitabina v\u00eda oral a dosis de 2500mg \/m2\/24h. Los animales fueron sacrificados a la semana 24 y fueron obtenidas las muestras.Se analizaron par\u00e1metros de estr\u00e9s oxidativo (lipoper\u00f3xidos, glutati\u00f3n reducido, super\u00f3xido desmutasa, glutati\u00f3n peroxidasa y catalasa) y se analiz\u00f3 hitol\u00f3gicamente la presencia o no de adenocarcinoma. Resultados: la presencia tumoral se redujo desde un 100% (grupo 2) hasta un 33% (grupo 3), un 66% (grupo 4) y un 10% (grupo 5). Los par\u00e1metros de estr\u00e9s oxidativo se redujeron con ambas terapias, si bien la capecitabina consigui\u00f3 niveles de lipoper\u00f3xidos m\u00e1s bajos, pero las tres modalidades terape\u00faticas mostraron aumento de las defensas antioxidantes. Conclusi\u00f3n: la adici\u00f3n de celecoxib a la capecitabina disminuye el estr\u00e9s oxidativo y tiene un efecto sin\u00e9rgico en la reducci\u00f3n tumoral en el c\u00e1ncer de p\u00e1ncreas experimental.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Celecoxib y capecitabina en el tratamiento de cancer de pancreas experimental<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Celecoxib y capecitabina en el tratamiento de cancer de pancreas experimental <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alvaro Arjona Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Rafael De La Haba Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Arevalo jimenez <\/li>\n<li>Fernando Docobo durantez (vocal)<\/li>\n<li>Jos\u00e9 Cantillana Martinez (vocal)<\/li>\n<li>Jes\u00fas Mar\u00eda Villar del moral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alvaro Arjona Sanchez En el c\u00e1ncer de p\u00e1ncreas la supervivencia es muy limitada y hoy en d\u00eda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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