{"id":93234,"date":"2009-11-05T00:00:00","date_gmt":"2009-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-protector-de-la-melatonina-en-la-cirrosis-hepatica-experimental-inducida-por-tioacemida\/"},"modified":"2009-11-05T00:00:00","modified_gmt":"2009-11-05T00:00:00","slug":"efecto-protector-de-la-melatonina-en-la-cirrosis-hepatica-experimental-inducida-por-tioacemida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-abdominal\/efecto-protector-de-la-melatonina-en-la-cirrosis-hepatica-experimental-inducida-por-tioacemida\/","title":{"rendered":"Efecto protector de la melatonina en la cirrosis hepatica experimental inducida por tioacemida"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Mar\u00eda Torres Tordera <\/strong><\/h2>\n<p>La cirrosis hep\u00e1tica es una enfermedad cr\u00f3nica que puede provocar fallo hep\u00e1tico, hipertensi\u00f3n portal y hepatocarcinoma. Esta relacionada con una elevada morbimortalidad y esto puede ser debido a virus, agentes t\u00f3xicos,  anormalidades gen\u00e9ticas, trastornos inmunol\u00f3gicos, etc. la fibrosis resulta de la activaci\u00f3n de sustancias de c\u00e9lulas como citoquinas y stress oxidativo. La inducci\u00f3n de stress oxidativo, disfunci\u00f3n mitocondrial y depleci\u00f3n de los niveles de antioxidantes es una caracter\u00edstica relevante en la progresi\u00f3n de la fibrosis y cirrosis hep\u00e1tica.. De acuerdo con la dosis y pauta de administraci\u00f3n de tioacetamida (taa) podemos provocar un fracaso hep\u00e1tico agudo o cirrosis hep\u00e1tica. La cirrosis hep\u00e1tica inducida por la taa esta asociada con la exacerbaci\u00f3n de peroxidacion lip\u00eddica y la depleci\u00f3n del nivel de antioxidantes. Por todo ello, la reducci\u00f3n del stress oxidativo puede ser una herramienta \u00fatil para reducir el da\u00f1o celular, cirrosis y fibrosis en m\u00faltiples enfermedades humanas y en modelos experimentales de disfunci\u00f3n hep\u00e1tica.  la melatonina (n-acetil 5methoxytryptaminea) es una amina de \u00edndole lipofilica derivada del tript\u00f3fano, producida exclusivamente en la gl\u00e1ndula pineal, pero recientemente ha sido detectada en muchos otros tejidos. Su eliminaci\u00f3n sigue un ritmo circadiano y se comporta como un neutralizador de radicales libres adem\u00e1s de citoprotector en varios modelos experimentales de lesi\u00f3n hep\u00e1tica aguda. Las sustancias de stress oxidativo juegan un papel importante en el da\u00f1o celular y la hepatotoxicidad inducida por un agente t\u00f3xico. El objetivo de este estudio ha sido evaluar los efectos de la melatonina sobre la lesi\u00f3n tisular, stress oxidativo y la activaci\u00f3n de enzimas antioxidantes durante la inducci\u00f3n de cirrosis hep\u00e1tica mediante la administraci\u00f3n a ratas de tioacetamida durante 4 \u00f3 12 semanas, midiendo posteriormente la lesi\u00f3n hep\u00e1tica mediante an\u00e1lisis serol\u00f3gicos, t\u00e9cnicas de hematoxilina-eosina y apoptosis, y enzimas antioxidantes, comprobando que la melatonina previene los cambios asociados a stress oxidativo por toxicidad inducida por tioacetamida.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto protector de la melatonina en la cirrosis hepatica experimental inducida por tioacemida<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto protector de la melatonina en la cirrosis hepatica experimental inducida por tioacemida <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Mar\u00eda Torres Tordera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adolfo Cruz Mu\u00f1oz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eugenio Arevalo jimenez <\/li>\n<li>Fernando Docobo durantez (vocal)<\/li>\n<li>Jos\u00e9 Cantillana Martinez (vocal)<\/li>\n<li>Jes\u00fas Mar\u00eda Villar del moral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Mar\u00eda Torres Tordera La cirrosis hep\u00e1tica es una enfermedad cr\u00f3nica que puede provocar fallo hep\u00e1tico, hipertensi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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