{"id":93339,"date":"2018-03-11T10:12:39","date_gmt":"2018-03-11T10:12:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analogos-fluorescentes-de-farmacos-lipa%c2%addicos-con-actividad-antiparasitaria-y-antineoplasica-diseno-sa%c2%adntesis-y-aplicaciones\/"},"modified":"2018-03-11T10:12:39","modified_gmt":"2018-03-11T10:12:39","slug":"analogos-fluorescentes-de-farmacos-lipa%c2%addicos-con-actividad-antiparasitaria-y-antineoplasica-diseno-sa%c2%adntesis-y-aplicaciones","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analogos-fluorescentes-de-farmacos-lipa%c2%addicos-con-actividad-antiparasitaria-y-antineoplasica-diseno-sa%c2%adntesis-y-aplicaciones\/","title":{"rendered":"An\u00e1logos fluorescentes de f\u00e1rmacos lip\u00eddicos con actividad antiparasitaria y antineopl\u00e1sica. dise\u00f1o, s\u00edntesis y aplicaciones."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Valentin Hornillos Gomez-recuero <\/strong><\/h2>\n<p>Null en la memoria se describe un conjunto de nuevos m\u00e9todos para el dise\u00f1o y la s\u00edntesis de an\u00e1logos fluorescentes de f\u00e1rmacos l\u00edpidos anfif\u00edlicos que mantienen esencialmente inalteradas las propiedades qu\u00edmico-f\u00edsicas y la bioactividad de las mol\u00e9culas originales. Estos m\u00e9todos se han aplicado a la s\u00edntesis de an\u00e1logos fluorescentes y bioactivos de hexadecilfosfocolina (miltefosina), un f\u00e1rmaco antiparasitario utilizado en el tratamiento de infecciones por leishmania. Se obtuvieron an\u00e1logos con  gr upos fluorescentes feniltrienino conjugado, 1,6-difenilhexatrieno o difluoroborodipirrometeno (bodipy), as\u00ed como an\u00e1logos con un grupo tiol adicional. Estos compuestos han proporcionado informaci\u00f3n original sobre el mecanismo antiparasitario de milte fosina. Asimismo, se han obtenido an\u00e1logos fluorescentes de 1-o-octadecil-2-o-metil-rac-glicero-3-fosfocolina (edelfosina), un \u00e9ter-l\u00edpido con actividad antitumoral selectiva, incluyendo en su estructura el grupo bodipy. Finalmente, se aplicaron los m\u00e9todos citados a la preparaci\u00f3n de an\u00e1logos de \u00e1cidos grasos de cadena lineal y de ceramidas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1logos fluorescentes de f\u00e1rmacos lip\u00eddicos con actividad antiparasitaria y antineopl\u00e1sica. dise\u00f1o, s\u00edntesis y aplicaciones.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1logos fluorescentes de f\u00e1rmacos lip\u00eddicos con actividad antiparasitaria y antineopl\u00e1sica. dise\u00f1o, s\u00edntesis y aplicaciones. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Valentin Hornillos Gomez-recuero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Ulises Acu\u00f1a Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Tejeda sojo <\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Valentin Hornillos Gomez-recuero Null en la memoria se describe un conjunto de nuevos m\u00e9todos para el dise\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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