{"id":93438,"date":"2018-03-11T10:12:47","date_gmt":"2018-03-11T10:12:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analogos-de-gramicidina-s-que-incorporan-fenilalaninas-modificadas\/"},"modified":"2018-03-11T10:12:47","modified_gmt":"2018-03-11T10:12:47","slug":"analogos-de-gramicidina-s-que-incorporan-fenilalaninas-modificadas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sintesis-de-peptidos\/analogos-de-gramicidina-s-que-incorporan-fenilalaninas-modificadas\/","title":{"rendered":"An\u00e1logos de gramicidina s que incorporan fenilalaninas modificadas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> M\u00aa Concepci\u00f3n Solanas D\u00edaz <\/strong><\/h2>\n<p>Gramicidina s es un decap\u00e9ptido c\u00edclico que posee actividad antimicrobiana. Esta mol\u00e9cula, de secuencia (val-orn-leu-d-phe-pro)2, presenta simetr\u00eda c2 y adopta una estructura de l\u00e1mina b bien definida, en la que los residuos de val, orn y leu se alinean para formar las hebras b antiparalelas, y donde d-phe y pro inducen giros de tipo b ii`. Adem\u00e1s, los residuos de val y leu, enfrentados en el esqueleto pept\u00eddico, forman puentes de hidr\u00f3geno que estabilizan la l\u00e1mina b. La capacidad antibi\u00f3tica de gramicidina s, sin embargo, viene acompa\u00f1ada por un efecto hemol\u00edtico notable, lo que limita su uso a aplicaciones t\u00f3picas. Con el fin de disociar ambos tipos de actividad existe un gran inter\u00e9s por el desarrollo de nuevos an\u00e1logos de este p\u00e9ptido. El presente estudio aborda la modificaci\u00f3n de la regi\u00f3n del giro b incorporando amino\u00e1cidos no proteicos en la posici\u00f3n ocupada por los dos residuos de d-phe. Asimismo, se ha realizado una inversi\u00f3n de la secuencia d-phe-pro, que ha sido reemplazada por d-pro-phe en ambos giros b. A su vez, se han sustituido los dos residuos de phe por otros derivados no proteicos. Los correspondientes p\u00e9ptidos lineales fueron preparados por s\u00edntesis en fase s\u00f3lida empleando qu\u00edmica boc, ciclados posteriormente en disoluci\u00f3n, purificados por hplc y caracterizados por espectrometr\u00eda de masas. Se ha evaluado la actividad biol\u00f3gica de los an\u00e1logos de gramicidina s sintetizados frente a distintos pat\u00f3genos. Adem\u00e1s, se han determinado las propiedades estructurales de estos p\u00e9ptidos utilizando t\u00e9cnicas de rmn. Todo ello ha permitido establecer correlaciones estructura-actividad, de gran utilidad en el dise\u00f1o de an\u00e1logos de gramicidina s con aplicaciones terap\u00e9uticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1logos de gramicidina s que incorporan fenilalaninas modificadas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1logos de gramicidina s que incorporan fenilalaninas modificadas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M\u00aa Concepci\u00f3n Solanas D\u00edaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/05\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Cativiela Mar\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: david Andreu mart\u00ednez <\/li>\n<li>M\u00aa \u00e1ngeles Jim\u00e9nez l\u00f3pez (vocal)<\/li>\n<li>Luis Rivas l\u00f3pez (vocal)<\/li>\n<li>Jos\u00e9 Luis Mascare\u00f1as cid (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M\u00aa Concepci\u00f3n Solanas D\u00edaz Gramicidina s es un decap\u00e9ptido c\u00edclico que posee actividad antimicrobiana. Esta mol\u00e9cula, de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1104,17670,147533,1097,13610],"tags":[9084,5628,51293,22320,135094,192973],"class_list":["post-93438","post","type-post","status-publish","format-standard","hentry","category-aminoacidos","category-diseno-sintesis-y-estudio-de-nuevos-farmacos","category-estructura-de-polipeptidos-y-proteinas","category-sintesis-de-peptidos","category-zaragoza","tag-carlos-cativiela-marin","tag-david-andreu-Martinez","tag-jose-luis-mascarenas-cid","tag-luis-rivas-lopez","tag-ma-angeles-jimenez-lopez","tag-ma-concepcion-solanas-diaz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/93438","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=93438"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/93438\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=93438"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=93438"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=93438"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}