{"id":93480,"date":"2018-03-11T10:12:53","date_gmt":"2018-03-11T10:12:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-cla%c2%adnica-molecular-e-inmunofenotipica-del-cancer-colorrectal-en-menores-de-45-anos\/"},"modified":"2018-03-11T10:12:53","modified_gmt":"2018-03-11T10:12:53","slug":"caracterizacion-cla%c2%adnica-molecular-e-inmunofenotipica-del-cancer-colorrectal-en-menores-de-45-anos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/caracterizacion-cla%c2%adnica-molecular-e-inmunofenotipica-del-cancer-colorrectal-en-menores-de-45-anos\/","title":{"rendered":"Caracterizaci\u00f3n cl\u00ednica, molecular e inmunofenotipica del c\u00e1ncer colorrectal en menores de 45 a\u00f1os"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Perea Garcia <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal (ccr) de aparici\u00f3n precoz es relativamente infrecuente, con una incidencia del 2-8%. Este grupo de edad presenta un abanico heterog\u00e9neo de casos, desde aquellos con una agregaci\u00f3n familiar importante para el ccr, hasta otros espor\u00e1dicos. La caracterizaci\u00f3n del ccr en el adulto joven no est\u00e1 todav\u00eda definida. Una proporci\u00f3n expresan caracter\u00edsticas similares al s\u00edndrome de lynch, con inestabilidad de microsat\u00e9lites (ims) en el tumor. El segundo grupo, con estabilidad de microsat\u00e9lites, poseer\u00eda un predominio de la v\u00eda de la inestabilidad cromos\u00f3mica.  analizados 45 individuos que presentaron ccr a una edad igual o menor  de 45 a\u00f1os, una proporci\u00f3n importante de los tumores se presentaron a nivel del colon derecho (44,4%), un predominio de tumores de moderado grado de diferenciaci\u00f3n, y un porcentaje de productores de moco  del 24,4%. Un tercio desarrollaron p\u00f3lipos en su evoluci\u00f3n. Destaca el estadio avanzado del ccr en m\u00e1s de la mitad de los casos. El 40% mostr\u00f3 agregaci\u00f3n familiar de ccr o neoplasias asociadas al s\u00edndrome de lynch.   el retraso en el diagn\u00f3stico condiciona el pron\u00f3stico. Tambi\u00e9n la localizaci\u00f3n izquierda a nivel del colon, o la activaci\u00f3n de la ruta wnt, o la falta de expresi\u00f3n de la ciclina e en los tumores.   el 31% present\u00f3 ims, siendo el 61% de ellos consecuencia de mutaciones germinales en mlh1 y msh2. Estos tumores presentaron caracter\u00edsticas diferenciales, como la edad de diagn\u00f3stico, m\u00e1s precoz, o la presencia mayor n\u00famero de antecedentes familiares neopl\u00e1sicos. Parecen tener un mejor pron\u00f3stico, aunque en un subgrupo no es as\u00ed (aquellos con c\u00e9lulas en \u00abanillo de sello\u00bb o con falta de expresi\u00f3n de p53).   tanto la asociaci\u00f3n de p\u00f3lipos como la frecuencia de neoplasias sincr\u00f3nicas y metacr\u00f3nicas (6,7%), condicionar\u00edan la necesidad de un seguimiento especial, y, en algunos casos, una cirug\u00eda m\u00e1s extensa que en el ccr espor\u00e1dico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n cl\u00ednica, molecular e inmunofenotipica del c\u00e1ncer colorrectal en menores de 45 a\u00f1os<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n cl\u00ednica, molecular e inmunofenotipica del c\u00e1ncer colorrectal en menores de 45 a\u00f1os <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Perea Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/05\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Urioste Azcorra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alberto Gomez alonso <\/li>\n<li>Manuel Hidalgo pascual (vocal)<\/li>\n<li>felipe angel Calvo manuel (vocal)<\/li>\n<li>Manuel Lomas espadas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Perea Garcia El c\u00e1ncer colorrectal (ccr) de aparici\u00f3n precoz es relativamente infrecuente, con una incidencia del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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