{"id":93555,"date":"2018-03-11T10:12:58","date_gmt":"2018-03-11T10:12:58","guid":{"rendered":""},"modified":"2018-03-11T10:12:58","modified_gmt":"2018-03-11T10:12:58","slug":"la-hipoxia-induce-la-activacion-de-los-macrofagos-potenciando-la-fagocitosis-y-la-presentacion-antigenica-a-traves-de-la-produccion-de-ifn-gamma-mediada-por-el-factor-de-transcripcion-hif-1-alfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-molecular\/la-hipoxia-induce-la-activacion-de-los-macrofagos-potenciando-la-fagocitosis-y-la-presentacion-antigenica-a-traves-de-la-produccion-de-ifn-gamma-mediada-por-el-factor-de-transcripcion-hif-1-alfa\/","title":{"rendered":"La hipoxia induce la activaci\u00f3n de los macr\u00f3fagos potenciando la fagocitosis y la presentaci\u00f3n antig\u00e9nica, a trav\u00e9s de la producci\u00f3n de ifn- gamma, mediada por el factor de transcripci\u00f3n hif-1 alfa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Barbara Acosta Iborra <\/strong><\/h2>\n<p>Low oxygen tension areas are found in inflamed or diseased tissues where hypoxic cells induce survival pathways by regulating the hypoxia-inducible transcription factor (hif). Macrophages are essential regulators of inflammation and, therefore, we have analyzed their response to hypoxia. Murine peritoneal elicited macrophages cultured under hypoxia produced higher levels of ifn-g and il-12 mrna and protein than those cultured under normoxia. A similar ifn- g increment was obtained with in vivo models using macrophages from mice exposed to atmospheric hypoxia. Our studies showed that ifn-g induction was mediated through hif-1a binding to its promoter on a new functional hypoxia response element. The requirement of hif-1a in the ifn-g induction was confirmed in raw264.7 cells, where hif-1a was knocked down, as well as in resident hif-1a null macrophages.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La hipoxia induce la activaci\u00f3n de los macr\u00f3fagos potenciando la fagocitosis y la presentaci\u00f3n antig\u00e9nica, a trav\u00e9s de la producci\u00f3n de ifn- gamma, mediada por el factor de transcripci\u00f3n hif-1 alfa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La hipoxia induce la activaci\u00f3n de los macr\u00f3fagos potenciando la fagocitosis y la presentaci\u00f3n antig\u00e9nica, a trav\u00e9s de la producci\u00f3n de ifn- gamma, mediada por el factor de transcripci\u00f3n hif-1 alfa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Barbara Acosta Iborra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/05\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Ort\u00edz De Land\u00e1zuri Busca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Fresno escudero <\/li>\n<li>gemma Olmos centenera (vocal)<\/li>\n<li>Mar\u00eda laura Garc\u00eda bermejo (vocal)<\/li>\n<li>angel Corbi lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Barbara Acosta Iborra Low oxygen tension areas are found in inflamed or diseased tissues where hypoxic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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