{"id":9368,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/disposicion-de-la-azitromicina-en-raton\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"disposicion-de-la-azitromicina-en-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/disposicion-de-la-azitromicina-en-raton\/","title":{"rendered":"Disposicion de la azitromicina en raton."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Idoya Gastearena Gorrochategui <\/strong><\/h2>\n<p>La azitromicina es un antibiotico macrolido de reciente aparicion en el mercado. Y en este estudio se ha llevado a cabo su caracterizacion farmacocinetica en el raton.  tras su administracion por via intravenosa se han determinado sus parametros en plasma y tejidos (vida media, aclaramiento, volumen de distribucion, area bajo la curva&#8230;).  el modelo que mejor ajusta los datos de concentracion-tiempo ha sido el bicompartimental.  asimismo se ha llevado a cabo la caracterizacion farmacocinetica tras la administracion oral con calculo de cmax, tmax, ka, auc, etc. La biodisponibilidad se ha estimado en un 49%. Por otro lado se han determinado los niveles de azitromicina en suero y en tejidos (higado y bazo) tras la administracion oral de dosis multiples en un modelo de infeccion murina por brucella melitensis.  por otro lado se ha determinado el grado de union de la azitromicina a las proteinas plasmaticas totales de raton (52%) y humanas (53%). Dicha union permanece constante en el intervalo de concentraciones ensayado.  tambien se ha comprobado la afinidad de la azitromicna por la albumina, resultando un grado de union del 32% y por la alpha 1 glicoproteina acida (30%).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Disposicion de la azitromicina en raton.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Disposicion de la azitromicina en raton. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Idoya Gastearena Gorrochategui <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Daniel Fos Galve<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Edurne Cenarruzabeitia Sagarminaga <\/li>\n<li>M\u00aa Bego\u00f1a Calvo Hernaez (vocal)<\/li>\n<li>Jos\u00e9 Luis Pedraz Mu\u00f1oz (vocal)<\/li>\n<li>Mar\u00eda Jes\u00fas Renedo Omaechevarr\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Idoya Gastearena Gorrochategui La azitromicina es un antibiotico macrolido de reciente aparicion en el mercado. Y en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,17749],"tags":[12341,17998,32143,3308,32145,32144],"class_list":["post-9368","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-navarra","tag-daniel-fos-galve","tag-edurne-cenarruzabeitia-sagarminaga","tag-idoya-gastearena-gorrochategui","tag-jose-luis-pedraz-munoz","tag-maria-jesus-renedo-omaechevarria","tag-ma-begona-calvo-hernaez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/9368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=9368"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/9368\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=9368"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=9368"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=9368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}