{"id":93692,"date":"2009-02-06T00:00:00","date_gmt":"2009-02-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronostico-del-melanoma-en-ninos-y-adolescentes-estudio-clinicopatologico-e-inmunohistoqua%c2%admico-en-137-casos-de-un-unico-centro\/"},"modified":"2009-02-06T00:00:00","modified_gmt":"2009-02-06T00:00:00","slug":"factores-pronostico-del-melanoma-en-ninos-y-adolescentes-estudio-clinicopatologico-e-inmunohistoqua%c2%admico-en-137-casos-de-un-unico-centro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/factores-pronostico-del-melanoma-en-ninos-y-adolescentes-estudio-clinicopatologico-e-inmunohistoqua%c2%admico-en-137-casos-de-un-unico-centro\/","title":{"rendered":"Factores pron\u00f3stico del melanoma en ni\u00f1os y adolescentes. estudio clinicopatol\u00f3gico e inmunohistoqu\u00edmico en 137 casos de un \u00fanico centro"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sabela Paradela De La Morena <\/strong><\/h2>\n<p>Fundamento el melanoma cut\u00e1neo en los ni\u00f1os es infrecuente, por lo que los factores que influyen en su pron\u00f3stico, su comportamiento biol\u00f3gico y la eficacia de las t\u00e9cnicas complementarias para su diagn\u00f3stico contin\u00faan siendo desconocidos.  objetivos revisar la experiencia acumulada en un centro oncol\u00f3gico de referencia mundial, para determinar qu\u00e9 factores influyen en el desarrollo de met\u00e1stasis y la mortalidad del melanoma cut\u00e1neo que aparece en menores de 18 a\u00f1os. material y m\u00e9todos estudio retrospectivo, observacional, sobre el significado pron\u00f3stico de las caracter\u00edsticas cl\u00ednicas e histol\u00f3gicas de 137 casos de melanoma en pacientes menores de 18 a\u00f1os referidos al ut-md anderson cancer center durante el periodo 1992-2006. resultados en el estudio univariado, los factores que se relacionaron con un mayor riesgo de met\u00e1stasis fueron: presencia de otra neoplasia, melanoma nodular, citolog\u00eda fusiforme o spitzoide, fase de crecimiento vertical, ulceraci\u00f3n y elevados \u00edndice de breslow, nivel de clark e \u00edndice mit\u00f3tico, quedando la invasi\u00f3n vascular en el l\u00edmite de la significaci\u00f3n estad\u00edstica.  doce pacientes (10,3%) murieron durante el seguimiento. El riesgo de muerte se asociaba significativamente con edad superior a 10 a\u00f1os, otras neoplasias, elevado \u00edndice de breslow y nivel de clark, estadio del ajcc y met\u00e1stasis en el momento del diagn\u00f3stico. Todos los ni\u00f1os que fallecieron eran mayores de 10 a\u00f1os y 8 de ellos ten\u00edan met\u00e1stasis en el momento del diagn\u00f3stico. en el estudio multivariado, el \u00edndice de breslow fue la variable que predijo el desarrollo de met\u00e1stasis y la edad y la existencia de met\u00e1stasis en el momento del diagn\u00f3stico, el riesgo de muerte. conclusiones al igual que en la poblaci\u00f3n adulta, la existencia de met\u00e1stasis en el momento del diagn\u00f3stico es uno de los factores principales que influyen en la supervivencia. Los melanomas detectados tras la pubertad parecen tener un comportamiento similar al que presentan en los adultos, mientras que los que aparecen en la etapa prepuberal se asocian a una supervivencia mayor.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pron\u00f3stico del melanoma en ni\u00f1os y adolescentes. estudio clinicopatol\u00f3gico e inmunohistoqu\u00edmico en 137 casos de un \u00fanico centro<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pron\u00f3stico del melanoma en ni\u00f1os y adolescentes. estudio clinicopatol\u00f3gico e inmunohistoqu\u00edmico en 137 casos de un \u00fanico centro <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sabela Paradela De La Morena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 A coru\u00f1a<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Fonseca Capdevila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felix Contreras rubio <\/li>\n<li>Jos\u00e9 Carlos Moreno gimenez (vocal)<\/li>\n<li>Carlos Ferr\u00e1ndiz foraster (vocal)<\/li>\n<li>salvio Serrano ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sabela Paradela De La Morena Fundamento el melanoma cut\u00e1neo en los ni\u00f1os es infrecuente, por lo que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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