{"id":9374,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/ciclosporina-a-y-adriamicina-ifosfamida-en-tumores-solidos-resistentes-un-estudio-clinico-e-inmunologico\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"ciclosporina-a-y-adriamicina-ifosfamida-en-tumores-solidos-resistentes-un-estudio-clinico-e-inmunologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/ciclosporina-a-y-adriamicina-ifosfamida-en-tumores-solidos-resistentes-un-estudio-clinico-e-inmunologico\/","title":{"rendered":"Ciclosporina a y adriamicina-ifosfamida en tumores solidos resistentes: un estudio clinico e inmunologico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramon Gonzalez Manzano <\/strong><\/h2>\n<p>Para comprobar si ciclosporina a (csa) puede revertir la resistencia clinica a quimioterapia, se dise\u00f1o un estudio clinico e inmunologico de fase i.El tratamiento consistio en csa 5 mg\/kg iv en 2 horas (dosis de carga), seguido de una infusion continua (ic) iv de 3 dias de csa a dosis que se escalaron desde 10 a 18 mg\/kg\/dia. La quimioterapia consistio en adriamicina 55 mg\/m2 en ic iv de 24 horas (dia 2) e ifosfamida 2 g\/m2 iv en 1 hora por dos dosis (dia 1 y 3). Los ciclos de tratamiento se repitieron cada 4 semanas.  treinta y ocho pacientes con tumores solidos resistentes tratados previamente recibieron un total de 112 ciclos.  la concentracion media de csa en estado de equilibrio de 2000 ng\/ml se alcanzo con una dosis de carga de 5 mg\/kg en 2 horas seguida de una ic iv de 3 dias a 16 mg\/kg\/dia o superior. La toxicidad hematologica fue mayor de lo esperable para la misma quimioterapia sola. Globalmente la toxicidad fue aceptable. No se apreciaron alteraciones en el numero total de linfocitos, ni en las subpoblaciones linfocitarias estudiadas (cd3, cd4, cd8, cd19) ni en el cociente cd4\/cd8 en los pacientes que recibieron mas de un ciclo de tratamiento. No obstante, hubo variaciones significativas y no uniformes en los valores de las diferentes subpoblaciones pre y post-tratamiento. Hubo tambien un aumento significativo del cociente cd4\/cd8. Se observaron regresiones tumorales en 6 pacientes (enfermedad de hodgkin, carcinoma epidermoide de cervix, cancer de mama, sarcoma de partes blandas y dos sarcomas de ewing). Todos ellos mostraban resistencia adquirida a tratamientos previos de quimioterapia.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ciclosporina a y adriamicina-ifosfamida en tumores solidos resistentes: un estudio clinico e inmunologico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ciclosporina a y adriamicina-ifosfamida en tumores solidos resistentes: un estudio clinico e inmunologico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramon Gonzalez Manzano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Brugarolas Masllorens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Esteban Santiago Calvo <\/li>\n<li>Fernando Vidal Vanaclocha (vocal)<\/li>\n<li> Garc\u00eda Puche Jos\u00e9 Luis (vocal)<\/li>\n<li>Alberto Biete Sola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramon Gonzalez Manzano Para comprobar si ciclosporina a (csa) puede revertir la resistencia clinica a quimioterapia, se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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