{"id":93812,"date":"2009-05-06T00:00:00","date_gmt":"2009-05-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-la-aromatasa-p450-en-los-prolactinomas-y-su-relacion-con-la-proliferacion-celular-y-la-apoptosis\/"},"modified":"2009-05-06T00:00:00","modified_gmt":"2009-05-06T00:00:00","slug":"expresion-de-la-aromatasa-p450-en-los-prolactinomas-y-su-relacion-con-la-proliferacion-celular-y-la-apoptosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-clinica\/expresion-de-la-aromatasa-p450-en-los-prolactinomas-y-su-relacion-con-la-proliferacion-celular-y-la-apoptosis\/","title":{"rendered":"Expresi\u00f3n de la aromatasa p450 en los prolactinomas y su relaci\u00f3n con la proliferaci\u00f3n celular y la apoptosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Manuel Larrinaga  Mendizabal <\/strong><\/h2>\n<p>La aromatizaci\u00f3n de la testosterona para producir estr\u00f3genos en la hip\u00f3fisis es un hecho demostrado, al igual que en los prolactinomas; tambi\u00e9n lo es el papel de los estr\u00f3genos en la g\u00e9nesis de estos tumores, no estando clara la correlaci\u00f3n de algunos factores que intervienen en la proliferaci\u00f3n celular (prote\u00edna p27 y el ant\u00edgeno nuclear de proliferaci\u00f3n celular -pcna-) y en los fen\u00f3menos de apoptosis (prote\u00edna bcl-2, y la caspasa 3 activa). se pretende profundizar en ello estudiando una serie de adenomas humanos (tumorales y no tumorales), analizando la proliferaci\u00f3n celular (la prote\u00edna p27 como inhibidora del ciclo celular y por tanto como factor antiproliferativo) y el estado de apoptosis, comprobando el comportamiento de la prote\u00edna antiapopt\u00f3tica bcl-2 y el de la caspasa 3 activa; todo ello correlacionado con la expresi\u00f3n de aromatasa p450, enzima responsable de la aromatizaci\u00f3n local de testosterona a estradiol. los prolactinomas humanos fueron siempre aromatasa positivos. Su \u00edndice de proliferaci\u00f3n aumenta considerablemente en relaci\u00f3n con las hip\u00f3fisis no tumorales. El estudio de la caspasa 3 activa permiti\u00f3 afirmar que la apoptosis en estos tumores es poco frecuente y que ning\u00fan tumor con proliferaci\u00f3n a pcna demostr\u00f3 poseer caspasa 3 activa. Los tumores con \u00edndices de actividad proliferativa elevada presentaron actividad positiva a la prote\u00edna antiapopt\u00f3tica bcl-2. La proteina p-27 se expres\u00f3 en casi todos los prolactinomas estudiados, principalmente en el citoplasma celular. los prolactinomas con \u00edndice de proliferaci\u00f3n alto y aromatasa positivos no presentaron c\u00e9lulas en apoptosis (caspasa 3 positivas). Los que presentaron marcaje nuclear positivo a p27 fueron negativos a caspasa 3 activa, sucediendo lo mismo con marcaje citopl\u00e1smico y nuclear de la p27; sin embargo, si hubo correlaci\u00f3n entre la caspasa 3 activa y la expresi\u00f3n citopl\u00e1smica de p27. No todos los tumores negativos a bcl-2 fueron positivos a caspasa 3 activa y ning\u00fan tumor positivo a bcl-2 fue caspasa 3 positivo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de la aromatasa p450 en los prolactinomas y su relaci\u00f3n con la proliferaci\u00f3n celular y la apoptosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de la aromatasa p450 en los prolactinomas y su relaci\u00f3n con la proliferaci\u00f3n celular y la apoptosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Manuel Larrinaga  Mendizabal <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Carretero Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 ignacio Paz bouza <\/li>\n<li>Antonio Gonz\u00e1lez gonz\u00e1lez (vocal)<\/li>\n<li>gines Domenech ratto (vocal)<\/li>\n<li>Jos\u00e9 Luis Bueno lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Manuel Larrinaga Mendizabal La aromatizaci\u00f3n de la testosterona para producir estr\u00f3genos en la hip\u00f3fisis es un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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