{"id":93915,"date":"2009-11-06T00:00:00","date_gmt":"2009-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacio-aa%c2%afllament-i-caracterizacio-de-ca%c2%a8la%c2%b7lules-mare-en-models-de-ca-ncer-de-pra%c2%b2stata\/"},"modified":"2009-11-06T00:00:00","modified_gmt":"2009-11-06T00:00:00","slug":"identificacio-aa%c2%afllament-i-caracterizacio-de-ca%c2%a8la%c2%b7lules-mare-en-models-de-ca-ncer-de-pra%c2%b2stata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/identificacio-aa%c2%afllament-i-caracterizacio-de-ca%c2%a8la%c2%b7lules-mare-en-models-de-ca-ncer-de-pra%c2%b2stata\/","title":{"rendered":"Identificaci\u00f3, a\u00c1\u00afllament i caracterizaci\u00f3 de c\u00e9l\u00c2\u00b7lules mare en models de c\u00c1\u00a0ncer de pr\u00f3stata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Albert Santamar\u00eda Mart\u00ednez <\/strong><\/h2>\n<p>Partiendo de la hip\u00f3tesis que existen c\u00e9lulas con caracter\u00edsticas de c\u00e9lulas madre en el c\u00e1ncer de pr\u00f3stata, el trabajo plantea los siguientes objetivos: identificar y aislar c\u00e9lulas de la side population (sp) tanto en tumores del modelo de xenotrasplante pac-120 como en las l\u00edneas celulares lncap y pc-3. Asimismo se plantea caracterizar los perfiles g\u00e9nicos de las c\u00e9lulas de la side population aisladas, comprobar su naturaleza progenitora mediante ensayos de diferenciaci\u00f3n in vitro y de tumorig\u00e9nesis in vivo. Por \u00faltimo, tambi\u00e9n se plantea determinar la existencia de c\u00e9lulas tumorales diseminadas en la m\u00e9dula \u00f3sea del modelo pac-120 y estudiar su posible naturaleza progenitora. Para la consecuci\u00f3n de los objetivos fijados en el trabajo se utilizan un modelo in vivo murino (el pac-120) y los modelos in vitro de l\u00edneas celulares de c\u00e1ncer de pr\u00f3stata (lncap y pc-3). Para identificar las c\u00e9lulas madre se propone el ensayo de la side population, dado que se ha demostrado su validez a la hora de identificar poblaciones enriquecidas en c\u00e9lulas madre y es un ensayo que proporciona informaci\u00f3n funcional sobre las c\u00e9lulas y permite aislarlas y caracterizarlas. en cuanto a los resultados obtenidos en el presente trabajo, se ha determinado que el pac-120 contiene c\u00e9lulas de la side population que son c\u00e9lulas multipotentes estromales (msc) procedentes del estroma murino mediante un an\u00e1lisis clonal de la sp. Se determina tambi\u00e9n que los clones responden a tgf-beta y que \u00e9ste regula proliferaci\u00f3n y diferenciaci\u00f3n en estas c\u00e9lulas. Adem\u00e1s, la diferenciaci\u00f3n de las msc provoca la p\u00e9rdida del fenotipo sp. Tambi\u00e9n se demuestra que hay un aumento en el porcentaje de sp en las m\u00e9dulas \u00f3seas de los animales que llevan el tumor pac-120 con respecto a los que no lo llevan. finalmente se demuestra que las l\u00edneas lncap y pc-3 presentan una sp y \u00e9sta est\u00e1 regulada por el estado de metilaci\u00f3n del promotor de abcg2 y, en el caso de lncap, por los estr\u00f3genos y el suero.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3, a\u00c1\u00afllament i caracterizaci\u00f3 de c\u00e9l\u00c2\u00b7lules mare en models de c\u00c1\u00a0ncer de pr\u00f3stata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3, a\u00c1\u00afllament i caracterizaci\u00f3 de c\u00e9l\u00c2\u00b7lules mare en models de c\u00c1\u00a0ncer de pr\u00f3stata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Albert Santamar\u00eda Mart\u00ednez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/2009<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francina Munell Casadesus<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: purificacion Mu\u00f1oz canoves <\/li>\n<li>anna Bigas salvans (vocal)<\/li>\n<li>  (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Albert Santamar\u00eda Mart\u00ednez Partiendo de la hip\u00f3tesis que existen c\u00e9lulas con caracter\u00edsticas de c\u00e9lulas madre en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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